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短期和长期暴露于空气污染会增加患缺血性心脏病的风险。

Short and long term exposure to air pollution increases the risk of ischemic heart disease.

机构信息

Department of Otorhinolaryngology-Head and Neck Surgery, CHA Bundang Medical Center, CHA University, Seongnam, South Korea.

Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam, South Korea.

出版信息

Sci Rep. 2021 Mar 3;11(1):5108. doi: 10.1038/s41598-021-84587-x.

DOI:10.1038/s41598-021-84587-x
PMID:33658616
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7930275/
Abstract

Previous studies have suggested an increased risk of ischemic heart disease related to air pollution. This study aimed to explore both the short-term and long-term effects of air pollutants on the risk of ischemic heart disease after adjusting for meteorological factors. The Korean National Health Insurance Service-Health Screening Cohort from 2002 to 2013 was used. Overall, 2155 participants with ischemic heart disease and 8620 control participants were analyzed. The meteorological data and air pollution data, including SO (ppm), NO (ppm), O (ppm), CO (ppm), and particulate matter (PM) (μg/m), were analyzed using conditional logistic regression. Subgroup analyses were performed according to age, sex, income, and region of residence. One-month exposure to SO was related to 1.36-fold higher odds for ischemic heart disease (95% confidence interval [95% CI] 1.06-1.75). One-year exposure to SO, O, and PM was associated with 1.58- (95% CI 1.01-2.47), 1.53- (95% CI 1.27-1.84), and 1.14 (95% CI 1.02-1.26)-fold higher odds for ischemic heart disease. In subgroup analyses, the ≥ 60-year-old group, men, individuals with low income, and urban groups demonstrated higher odds associated with 1-month exposure to SO. Short-term exposure to SO and long-term exposure to SO O, and PM were related to ischemic heart disease.

摘要

先前的研究表明，空气污染与缺血性心脏病的风险增加有关。本研究旨在探讨在调整气象因素后，空气污染物对缺血性心脏病风险的短期和长期影响。使用了 2002 年至 2013 年的韩国国家健康保险服务-健康筛查队列。总体上，分析了 2155 名缺血性心脏病患者和 8620 名对照参与者。使用条件逻辑回归分析气象数据和空气污染数据，包括 SO（ppm）、NO（ppm）、O（ppm）、CO（ppm）和颗粒物（PM）（μg/m）。根据年龄、性别、收入和居住地区进行了亚组分析。SO 暴露 1 个月与缺血性心脏病的发病风险增加 1.36 倍（95%置信区间 [95%CI] 1.06-1.75）有关。SO、O 和 PM 暴露 1 年与缺血性心脏病的发病风险增加 1.58 倍（95%CI 1.01-2.47）、1.53 倍（95%CI 1.27-1.84）和 1.14 倍（95%CI 1.02-1.26）有关。在亚组分析中，≥60 岁组、男性、低收入者和城市组的 SO 暴露 1 个月与更高的发病风险相关。SO 的短期暴露和 SO、O 和 PM 的长期暴露与缺血性心脏病有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7eb/7930275/d06bfbe27886/41598_2021_84587_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7eb/7930275/205af871d222/41598_2021_84587_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7eb/7930275/ced90d0a1216/41598_2021_84587_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7eb/7930275/9be7bcd8a70d/41598_2021_84587_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7eb/7930275/503f0b3dc82d/41598_2021_84587_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7eb/7930275/d06bfbe27886/41598_2021_84587_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7eb/7930275/205af871d222/41598_2021_84587_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7eb/7930275/ced90d0a1216/41598_2021_84587_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7eb/7930275/9be7bcd8a70d/41598_2021_84587_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7eb/7930275/503f0b3dc82d/41598_2021_84587_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7eb/7930275/d06bfbe27886/41598_2021_84587_Fig5_HTML.jpg

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