School of Physical Science and Technology, ShanghaiTech University, 393 Middle Huaxia Road, Shanghai, 201210, P. R. China.
Department of Chemistry & State Key Laboratory of Molecular Engineering of Polymers & Collaborative Innovation Center of Chemistry for Energy Materials, Fudan University, 2005 Songhu Road, Shanghai 200438, P. R. China.
Nanoscale Horiz. 2022 Sep 26;7(10):1177-1185. doi: 10.1039/d2nh00283c.
Lanthanide luminescence nanothermometers (LNTs) provide microscopic, highly sensitive, and visualizable optical signals for reporting temperature information, which is particularly useful in biomedicine to achieve precise diagnosis and therapy. However, LNTs with efficient emissions at the long-wavelength region of the second and the third near-infrared (NIR-II/III) biological window, which is more favourable for thermometry, are still limited. Herein, we present a lanthanide-doped nanocomposite with Tm and Nd ions as emitters working beyond 1200 nm to construct a dual ratiometric LNT. The cross-relaxation processes among lanthanide ions are employed to establish a strategy to enhance the NIR emissions of Tm for bioimaging-based temperature detection . The dual ratiometric probes included in the nanocomposite have potential in monitoring the temperature difference and heat transfer at the nanoscale, which would be useful in modulating the heating operation more precisely during thermal therapy and other biomedical applications. This work not only provides a powerful tool for temperature sensing but also proposes a method to build high-efficiency NIR-II/III lanthanide luminescent nanomaterials for broader bio-applications.
镧系元素发光纳米温度计 (LNTs) 提供微观、高灵敏度和可视化的光学信号，用于报告温度信息，这在生物医学中特别有用，可以实现精确的诊断和治疗。然而，在第二和第三近红外 (NIR-II/III) 生物窗口的长波长区域具有高效发射的 LNTs 仍然有限。在此，我们提出了一种掺杂 Tm 和 Nd 离子的镧系元素纳米复合材料作为发射器，工作波长超过 1200nm，以构建双比率 LNT。镧系离子的交叉弛豫过程被用于建立一种策略，以增强 Tm 的近红外发射，用于基于生物成像的温度检测。纳米复合材料中包含的双比率探针有可能监测纳米尺度的温差和热传递，这对于在热疗和其他生物医学应用中更精确地调节加热操作非常有用。这项工作不仅为温度传感提供了有力的工具，而且还提出了一种构建高效 NIR-II/III 镧系发光纳米材料的方法，以扩大其在生物医学中的应用。
