Department of Medicine, New York University (NYU) Langone Medical Center, New York, New York, USA.
Division of Medical Ethics, Department of Population Health, NYU Grossman School of Medicine, New York, New York, USA.
CA Cancer J Clin. 2022 Nov;72(6):561-569. doi: 10.3322/caac.21753. Epub 2022 Aug 15.
Human papillomavirus (HPV) is currently linked to almost 35,000 new cases of cancer in women and men each year in the United States. Gardasil-9 (Merck & Company), the only HPV vaccine now available in the United States, is nearly 100% effective at preventing precancers caused by oncogenic HPV types. In the United States, however, only about one half of adolescents are up to date with HPV vaccination. It is well known that health care clinicians' recommendations play a significant role in parents' decisions regarding HPV vaccination. A growing body of literature examines specific communication strategies for promoting uptake of the HPV vaccine. A comprehensive review of the evidence for each of these strategies is needed. The authors searched the PubMed, EMBASE, Cochrane Central Register of Controlled Trials, PsycINFO, Cumulative Index to Nursing and Allied Health Literature, and Web of Science Complete databases for original articles with a defined clinician communication strategy and an outcome of HPV vaccine uptake or intention to vaccinate (PROSPERO registry no. CRD42020107602). In total, 46 studies were included. The authors identified two main strategies with strong evidence supporting their positive impact on vaccine uptake: strong recommendation and presumptive recommendation. Determinations about a causal relationship were limited by the small numbers of randomized controlled trials. There is also opportunity for more research to determine the effects of motivational interviewing and cancer-prevention messaging.
人乳头瘤病毒（HPV）目前每年在美国导致近 35000 例新的男性和女性癌症病例。Gardasil-9（默克公司）是目前美国唯一可用的 HPV 疫苗，对预防致癌 HPV 类型引起的癌前病变的有效性接近 100%。然而，在美国，只有大约一半的青少年接受了 HPV 疫苗接种的最新情况。众所周知，医疗保健临床医生的建议在父母决定 HPV 疫苗接种方面发挥着重要作用。越来越多的文献研究了促进 HPV 疫苗接种的具体沟通策略。需要对这些策略中的每一种策略的证据进行全面审查。作者在 PubMed、EMBASE、Cochrane 中央对照试验注册中心、PsycINFO、护理和联合健康文献累积索引和 Web of Science Complete 数据库中搜索了具有明确临床医生沟通策略和 HPV 疫苗接种或接种意向结果的原始文章（PROSPERO 注册号 CRD42020107602）。共有 46 项研究被纳入。作者确定了两种主要策略，有强有力的证据支持它们对疫苗接种的积极影响：强烈推荐和假设推荐。由于随机对照试验的数量较少，因此对因果关系的判断有限。还有机会进行更多的研究来确定动机性访谈和癌症预防信息传递的效果。
