Key Laboratory of Physical Fitness and Exercise Rehabilitation of Hunan Province, Hunan Normal University, Changsha, China.
Aging (Albany NY). 2022 Aug 14;14(15):6338-6357. doi: 10.18632/aging.204225.
It is well-established that SPIB is essential for the survival of mature B cells, playing a key role in diffuse large B-cell lymphoma, colorectal cancer, and lung cancer. However, no study has hitherto conducted a systematic pan-cancer analysis on SPIB. Herein, we analyzed the differential expression of SPIB in pan-cancer using The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) databases and found that SPIB was significantly upregulated in most cancers. In addition, SPIB was positively or negatively associated with prognosis in different cancers. We found that SPIB was significantly associated with tumor immune infiltration and immune checkpoint genes in more than 35 tumors by TIMER database analysis. In addition, SPIB was negatively correlated with Tumor mutational burden (TMB) and Microsatellite instability (MSI) in most tumors. Finally, GO/KEGG enrichment analysis revealed the possible involvement of SPIB in NF-kappa B and B-cell receptor signaling pathways. In conclusion, our comprehensive pan-cancer analysis of SPIB reveals its important role in tumor immunity, suggesting it has huge prospects for clinical application in cancer therapy.
已有大量研究证实，SPIB 对于成熟 B 细胞的存活至关重要，在弥漫性大 B 细胞淋巴瘤、结直肠癌和肺癌中发挥着关键作用。然而，目前尚无研究对 SPIB 进行系统的泛癌症分析。本研究利用癌症基因组图谱（TCGA）和基因-组织表达（GTEx）数据库分析了 SPIB 在泛癌症中的差异表达，结果发现 SPIB 在大多数癌症中显著上调。此外，SPIB 与不同癌症的预后呈正相关或负相关。通过 TIMER 数据库分析，我们发现 SPIB 与超过 35 种肿瘤的肿瘤免疫浸润和免疫检查点基因显著相关。此外，SPIB 与大多数肿瘤的肿瘤突变负担（TMB）和微卫星不稳定性（MSI）呈负相关。最后，GO/KEGG 富集分析表明 SPIB 可能参与 NF-κB 和 B 细胞受体信号通路。综上所述，我们对 SPIB 的全面泛癌症分析揭示了其在肿瘤免疫中的重要作用，提示其在癌症治疗的临床应用中具有广阔的前景。
