小儿唾液恶性肿瘤的外科治疗-单中心队列研究。
Surgical management of pediatric salivary malignant tumors-A single-center cohort study.
机构信息
Department of Surgery, Head & Neck Service, Memorial Sloan Kettering Cancer Center, New York City, New York, USA.
Division of Pediatric Head & Neck Surgery, AdventHealth For Children, Orlando, Florida, USA.
出版信息
J Surg Oncol. 2022 Dec;126(8):1389-1395. doi: 10.1002/jso.27063. Epub 2022 Aug 15.
BACKGROUND
The purpose of this study was to report incidence, clinicopathologic behavior, management, and outcome of pediatric patients treated surgically for salivary gland (SG) malignancies.
METHODS
Patients who underwent surgery for SG malignancies from 1985 to 2015 were identified. Clinical, pathological, treatment and outcomes data were collected. Disease-specific survival (DSS), recurrence-free survival (RFS), and overall survival (OS) were calculated using Kaplan-Meier method.
RESULTS
Twenty-eight pediatric patients were included. The most common histopathological types were mucoepidermoid (n = 18, 64.3%), acinic cell (n = 7, 25.0%), adenoid cystic (n = 2, 7.1%), and adenocarcinoma (n = 1, 3.6%). Surgical approach varied and ranged from superficial parotidectomy (n = 11, 39.3%) to partial maxillectomy (n = 6, 21.4%). Nine patients (32%) required postoperative radiotherapy. DSS, OS, and RFS probability at 5 years were 96.4%, 96.4%, and 89.3%, respectively.
CONCLUSION
Pediatric SG malignancies are rare and have favorable outcome at 5 years. Larger, multi-institutional studies are required to better understand the natural history of these rare tumors.
背景
本研究旨在报告接受手术治疗的儿童涎腺（SG）恶性肿瘤患者的发病率、临床病理行为、治疗方法和结局。
方法
回顾性分析了 1985 年至 2015 年间接受手术治疗的 SG 恶性肿瘤患者的临床、病理、治疗和结局数据。采用 Kaplan-Meier 法计算疾病特异性生存（DSS）、无复发生存（RFS）和总生存（OS）。
结果
共纳入 28 例儿童患者。最常见的组织病理学类型为黏液表皮样癌（n=18，64.3%）、腺泡细胞癌（n=7，25.0%）、腺样囊性癌（n=2，7.1%）和腺癌（n=1，3.6%）。手术方式各异，包括腮腺浅叶切除术（n=11，39.3%）至上颌骨部分切除术（n=6，21.4%）。9 例（32%）患者术后需行放疗。5 年 DSS、OS 和 RFS 概率分别为 96.4%、96.4%和 89.3%。
结论
儿童 SG 恶性肿瘤罕见，但 5 年生存率较高。需要更大规模的多机构研究来更好地了解这些罕见肿瘤的自然病程。
Zotero 插件