Grant Stephen R, Grosshans David R, Bilton Stephen D, Garcia John A, Amin Mayank, Chambers Mark S, McGovern Susan L, McAleer Mary F, Morrison William H, Huh Winston W, Kupferman Michael E, Mahajan Anita
Baylor College of Medicine, Houston, United States.
Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, United States.
Radiother Oncol. 2015 Aug;116(2):309-15. doi: 10.1016/j.radonc.2015.07.022. Epub 2015 Jul 28.
We evaluated acute toxicity profiles and dosimetric data for children with salivary gland tumors treated with adjuvant photon/electron-based radiation therapy (X/E RT) or proton therapy (PRT).
We identified 24 patients who had received adjuvant radiotherapy for salivary gland tumors. Data were extracted from the medical records and the treatment planning systems. Toxicity was scored according to the Common Terminology Criteria for Adverse Effects 4.0.
Eleven patients received X/E RT and 13 PRT, with a median prescribed dose of 60 Gy in each group. In the X/E RT group, 54% of patients developed acute grade II/III dermatitis, 27% grade II/III dysphagia, and 91% grade II/III mucositis, and the median weight loss was 5.3% with one patient requiring feeding tube placement. In the PRT group, 53% had acute grade II/III dermatitis, 0% grade II/III dysphagia, and 46% grade II/III mucositis, with a median weight gain of 1.2%. Additionally, PRT was associated with lower mean doses to several normal surrounding midline and contralateral structures.
In this retrospective study of pediatric salivary tumors, PRT was associated with a favorable acute toxicity and dosimetric profile. Continued follow-up is needed to identify long-term toxicity and survival data.
我们评估了接受辅助性基于光子/电子的放射治疗（X/E RT）或质子治疗（PRT）的涎腺肿瘤患儿的急性毒性概况和剂量测定数据。
我们确定了24例接受涎腺肿瘤辅助放疗的患者。数据从病历和治疗计划系统中提取。根据不良事件通用术语标准4.0对毒性进行评分。
11例患者接受X/E RT，13例接受PRT，每组的中位处方剂量为60 Gy。在X/E RT组中，54%的患者出现急性II/III级皮炎，27%出现II/III级吞咽困难，91%出现II/III级粘膜炎，中位体重减轻5.3%，1例患者需要放置饲管。在PRT组中，53%的患者出现急性II/III级皮炎，0%出现II/III级吞咽困难，46%出现II/III级粘膜炎，中位体重增加1.2%。此外，PRT与周围几个正常中线和对侧结构的较低平均剂量相关。
在这项小儿涎腺肿瘤的回顾性研究中，PRT与良好的急性毒性和剂量测定概况相关。需要持续随访以确定长期毒性和生存数据。
