手术在儿童黏液表皮样癌治疗中的首要地位。
Primacy of surgery in the management of mucoepidermoid carcinoma in children.
机构信息
Department of Otolaryngology, National Naval Medical Center, Bethesda, Maryland, USA.
出版信息
Head Neck. 2011 Dec;33(12):1769-73. doi: 10.1002/hed.21675. Epub 2011 Jan 31.
BACKGROUND
Epithelial salivary gland neoplasms are rare in children. Malignant tumors account for 30% to 50% of cases in the pediatric age group, with mucoepidermoid carcinoma as the most common histology.
METHODS
A retrospective medical record review was conducted from 1953 to 2007 to identify patients with mucoepidermoid carcinoma at the age of 18 years or younger at the time of diagnosis. Forty-nine patients were identified. Their medical records were examined for presentation, treatment, pathologic features, and outcomes.
RESULTS
Forty-nine pediatric patients with mucoepidermoid carcinoma were identified. The parotid gland (49%) and oral cavity (35%) were the most common subsites. Nodal metastasis was seen in 24% of patients. All patients underwent surgery, and 11 patients (22%) were treated with radiation therapy. The 5-year overall survival was 98%, the 10-year overall survival was 94%, and 10% of patients developed recurrence.
CONCLUSION
Mucoepidermoid carcinoma in children carries a favorable prognosis and can be successfully treated with surgery alone in most cases.
背景
儿童唾液腺上皮性肿瘤较为罕见。在儿科年龄段，恶性肿瘤占 30%至 50%，其中黏液表皮样癌最为常见。
方法
我们对 1953 年至 2007 年的病历进行了回顾性研究，以确定诊断时年龄在 18 岁以下的黏液表皮样癌患者。共确定了 49 例患者。我们对其病历进行了检查，以了解其临床表现、治疗、病理特征和结局。
结果
共确定了 49 例患有黏液表皮样癌的儿科患者。最常见的发病部位是腮腺（49%）和口腔（35%）。24%的患者发生淋巴结转移。所有患者均接受了手术治疗，11 例患者（22%）接受了放射治疗。5 年总生存率为 98%，10 年总生存率为 94%，10%的患者复发。
结论
儿童黏液表皮样癌预后良好，大多数情况下单独手术即可治愈。
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