Department of Dermatology, Suining First People's Hospital, Suining, 629000, Sichuan, China.
The Central Laboratory, Affiliated Hospital of Putian University, Putian, China.
Hum Cell. 2022 Nov;35(6):1640-1649. doi: 10.1007/s13577-022-00768-4. Epub 2022 Aug 15.
Long non-coding RNAs (lncRNAs) are a type of multifunctional endogenous RNA transcript. The dysregulation of lncRNAs is considered to play a role in the initiation and progression of cancer. One such lncRNA, long intergenic non-coding RNA-p21 (lincRNA-p21), was identified in 2010 as a regulator in the p53 pathway and is gradually being identified to play crucial roles in diverse cellular processes. In this review, we have summarised the diverse regulatory functions of lincRNA-p21. For example, lincRNA-p21 has been reported to function as a protein decoy, act as a competitive endogenous RNA, regulate the transcription, regulate the translation processes and exist in the secreted exosomes. Furthermore, we highlight the emerging roles of lincRNA-p21 in cancer cell regulation. Various types of cancers, including colorectal carcinoma, hepatocellular carcinoma and non-small cell lung carcinoma, aberrantly express lincRNA-p21. However, the current understanding of the roles of lincRNA-p21 in cancer remains limited. Therefore, considering its potential as a valuable therapeutic target or biomarker for cancer, more research should be conducted to understand the role of lincRNA-p21 in cancer and other diseases.
长非编码 RNA（lncRNAs）是一种多功能的内源性 RNA 转录本。lncRNAs 的失调被认为在癌症的发生和发展中起作用。其中一种 lncRNA，长基因间非编码 RNA-p21（lincRNA-p21）于 2010 年被确定为 p53 途径的调节因子，并逐渐被确定在多种细胞过程中发挥关键作用。在这篇综述中，我们总结了 lincRNA-p21 的多种调节功能。例如，已经报道 lincRNA-p21 作为一种蛋白质诱饵发挥作用，作为一种竞争性内源性 RNA 发挥作用，调节转录，调节翻译过程，并存在于分泌的外泌体中。此外，我们强调了 lincRNA-p21 在癌细胞调节中的新兴作用。各种类型的癌症，包括结直肠癌、肝细胞癌和非小细胞肺癌，异常表达 lincRNA-p21。然而，目前对 lincRNA-p21 在癌症中的作用的理解仍然有限。因此，考虑到它作为癌症有价值的治疗靶点或生物标志物的潜力，应该进行更多的研究来了解 lincRNA-p21 在癌症和其他疾病中的作用。
