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膳食脂肪对大鼠学习、痛阈、体温调节及运动活动的影响:与喂养期时长的相互作用

Effects of dietary fats on learning, pain threshold, thermoregulation and motor activity in rats: interaction with the length of feeding period.

作者信息

Yehuda S, Carasso R L

出版信息

Int J Neurosci. 1987 Feb;32(3-4):919-25. doi: 10.3109/00207458709043348.

DOI:10.3109/00207458709043348
PMID:3596936
Abstract

The effects of both a semisynthetic diet containing 20% fat from various sources (soybean oil, sunflower oil and lard) and a control diet on learning capacity, motor activity, pain threshold and thermoregulation were studied in rats which were fed on these diets for various lengths of feeding periods (1, 2, 3 and 4 weeks). Two weeks feeding period of soybean oil source induced an improvement in learning capacity, which was further enhanced by increasing the length of the feeding period. A 3-week feeding period was required to obtain an increase in the pain threshold, by which time the rats were also protected from d-amphetamine induced hypothermia. The analgesia induced by the diet is naloxone-dependent. None of the other diets, including the sunflower oil diet, which is richer in polyunsaturated fatty acids, differed from control diet. While the mode of action of this diet is still unknown, the effects of the soybean oil source diet cannot be attributed to nutritional factors such as changes in energy consumption or body weight.

摘要

研究了含20%来自不同来源脂肪(大豆油、葵花籽油和猪油)的半合成饮食和对照饮食对大鼠学习能力、运动活性、痛阈和体温调节的影响,这些大鼠分别喂食这些饮食不同时长(1、2、3和4周)。以大豆油为来源的饮食喂养两周可提高学习能力,延长喂养时间可进一步增强这种能力。需要3周的喂养期才能提高痛阈,此时大鼠也受到保护,免受右旋苯丙胺诱导的体温过低影响。该饮食诱导的镇痛作用依赖于纳洛酮。包括富含多不饱和脂肪酸的葵花籽油饮食在内的其他饮食与对照饮食均无差异。虽然这种饮食的作用方式尚不清楚,但大豆油来源饮食的效果不能归因于能量消耗或体重变化等营养因素。

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Neurotox Res. 2010 Apr;17(3):228-37. doi: 10.1007/s12640-009-9095-0. Epub 2009 Jul 31.
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Modulation of learning and neuronal membrane composition in the rat by essential fatty acid preparation: time-course analysis.必需脂肪酸制剂对大鼠学习及神经元膜成分的调节:时间进程分析
Neurochem Res. 1998 May;23(5):627-34. doi: 10.1023/a:1022430620205.
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Dietary saturated fatty acids and brain function.
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