Yehuda S, Rabinovitz S, Mostofsky D I
Department of Psychology, Bar Ilan University, Ramat Gan, Israel.
Neurochem Res. 1998 May;23(5):627-34. doi: 10.1023/a:1022430620205.
Previous studies have shown that chronic administration of SR-3 (a 1:4 mixture of alpha-linolenic and linoleic acid) affects spatial learning, thermoregulation, pain threshold and protection from seizures. The mode of action is unknown. One possible explanation is that the preparation induces changes in the fatty acids profile and in the cholesterol level in the neuronal membrane. This study used 15 independent groups of rats (n = 12) which were given either saline, mineral oil (vehicle) or SR-3 (25 mg/kg) for 0, 1, 2, 3, or 4 weeks. The learning performance was measured in the Morris Water tank and the fatty acids profile and the cholesterol level were examined by the GC method in synaptosomes obtained from the frontal cortex of the rats. SR-3 improved the learning performance and induced major changes in the neuronal membrane composition, such as an increase in the total level of fatty acids, an increase in the level of essential fatty acids and a decrease in the cholesterol level. Those changes occurred after 3 weeks of treatment. The biochemical variables can predict the behavioral variables but not vice versa. The changes in the neuronal membrane may result in a modification of the membrane fluidity, which may, in turn, enhance cognitive and neuropharmacological effects.
先前的研究表明，长期给予SR-3（α-亚麻酸和亚油酸的1:4混合物）会影响空间学习、体温调节、痛阈和抗癫痫能力。其作用方式尚不清楚。一种可能的解释是，该制剂会引起神经元膜中脂肪酸谱和胆固醇水平的变化。本研究使用了15个独立的大鼠组（每组n = 12），分别给予生理盐水、矿物油（赋形剂）或SR-3（25 mg/kg），持续0、1、2、3或4周。在莫里斯水迷宫中测量学习能力，并通过气相色谱法检测从大鼠额叶皮质获得的突触体中的脂肪酸谱和胆固醇水平。SR-3改善了学习能力，并引起神经元膜组成的主要变化，如脂肪酸总水平增加、必需脂肪酸水平增加和胆固醇水平降低。这些变化在治疗3周后出现。生化变量可以预测行为变量，但反之则不然。神经元膜的变化可能导致膜流动性的改变，进而可能增强认知和神经药理学效应。
