Engineering of Near-Infrared-Activated Lignin-Polydopamine-Nanosilver Composites for Highly Efficient Sterilization.

Photothermal synergistic antimicrobial therapy is considered a promising strategy to cope with antibiotic-resistant bacterial infections. In this work, lignin-based polydopamine nanosilver composites (LS-PDA-Ag) were engineered by a two-step process including self-assembly and microwave-assisted reduction. First, sodium lignosulfonate (LS) was not only used as a carrier to disperse polydopamine (PDA) and silver nanoparticles (AgNPs), but also used to reduce Ag for producing AgNPs. Second, PDA could promote the reduction of Ag and enhance the photothermal effect of AgNPs to further improve antibacterial efficiency. Finally, LS, AgNPs, and PDA complement each other, forming a synergistic photothermal antibacterial mechanism, achieving efficient bacterial killing within a short time. The antibacterial test of LS-PDA-Ag confirmed that 7.6 log CFU/mL of were killed in 10 min under near-infrared irradiation. Furthermore, the LS-PDA-Ag can be blended with waterborne polyurethane to synthesize hybrid films, which also results in rapid sterilization and mechanical performance improvement. Considering the highly effective antibacterial activity of the LS-PDA-Ag composite, this work may provide perspectives on the design of green photothermal antibacterial materials.