Zhang Yingchun, Wang Yalin, Li Zhixian, Yang Dongjie, Qiu Xueqing
School of Chemistry and Chemical Engineering, Guangdong Provincial Engineering Research Center for Green Fine Chemicals, South China University of Technology, 381 Wushan Road, Tianhe District, Guangzhou 510641, China.
School of Chemical Engineering and Light Industry, Guangdong University of Technology, 100 Waihuan Xi Road, Panyu District, Guangzhou 510006, China.
ACS Appl Bio Mater. 2022 Aug 15. doi: 10.1021/acsabm.2c00474.
Photothermal synergistic antimicrobial therapy is considered a promising strategy to cope with antibiotic-resistant bacterial infections. In this work, lignin-based polydopamine nanosilver composites (LS-PDA-Ag) were engineered by a two-step process including self-assembly and microwave-assisted reduction. First, sodium lignosulfonate (LS) was not only used as a carrier to disperse polydopamine (PDA) and silver nanoparticles (AgNPs), but also used to reduce Ag for producing AgNPs. Second, PDA could promote the reduction of Ag and enhance the photothermal effect of AgNPs to further improve antibacterial efficiency. Finally, LS, AgNPs, and PDA complement each other, forming a synergistic photothermal antibacterial mechanism, achieving efficient bacterial killing within a short time. The antibacterial test of LS-PDA-Ag confirmed that 7.6 log CFU/mL of were killed in 10 min under near-infrared irradiation. Furthermore, the LS-PDA-Ag can be blended with waterborne polyurethane to synthesize hybrid films, which also results in rapid sterilization and mechanical performance improvement. Considering the highly effective antibacterial activity of the LS-PDA-Ag composite, this work may provide perspectives on the design of green photothermal antibacterial materials.
光热协同抗菌疗法被认为是应对抗生素耐药性细菌感染的一种有前景的策略。在这项工作中，通过包括自组装和微波辅助还原的两步法制备了木质素基聚多巴胺纳米银复合材料（LS-PDA-Ag）。首先，木质素磺酸钠（LS）不仅用作分散聚多巴胺（PDA）和银纳米颗粒（AgNPs）的载体，还用于还原Ag以制备AgNPs。其次，PDA可以促进Ag的还原并增强AgNPs的光热效应，从而进一步提高抗菌效率。最后，LS、AgNPs和PDA相互补充，形成协同光热抗菌机制，在短时间内实现高效杀菌。LS-PDA-Ag的抗菌测试证实，在近红外照射下，10分钟内可杀死7.6 log CFU/mL的[细菌]。此外，LS-PDA-Ag可以与水性聚氨酯共混以合成杂化膜，这也导致快速杀菌并改善机械性能。考虑到LS-PDA-Ag复合材料的高效抗菌活性，这项工作可能为绿色光热抗菌材料的设计提供思路。
