Liu Qiuyue, Zou Jiahui, Chen Zhongjian, He Wei, Wu Wei
Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai 200443, China.
Key Laboratory of Smart Drug Delivery of MOE, School of Pharmacy, Fudan University, Shanghai 201203, China.
Acta Pharm Sin B. 2023 Nov;13(11):4391-4416. doi: 10.1016/j.apsb.2023.05.018. Epub 2023 May 20.
Owing to the inherent shortcomings of traditional therapeutic drugs in terms of inadequate therapeutic efficacy and toxicity in clinical treatment, nanomedicine designs have received widespread attention with significantly improved efficacy and reduced non-target side effects. Nanomedicines hold tremendous theranostic potential for treating, monitoring, diagnosing, and controlling various diseases and are attracting an unfathomable amount of input of research resources. Against the backdrop of an exponentially growing number of publications, it is imperative to help the audience get a panorama image of the research activities in the field of nanomedicines. Herein, this review elaborates on the development trends of nanomedicines, emerging nanocarriers, fate and safety of nanomedicines, and their extensive applications. Moreover, the potential challenges and the obstacles hindering the clinical translation of nanomedicines are also discussed. The elaboration on various aspects of the research trends of nanomedicines may help enlighten the readers and set the route for future endeavors.
由于传统治疗药物在临床治疗中存在治疗效果不佳和毒性等固有缺点,纳米医学设计因疗效显著提高和非靶向副作用减少而受到广泛关注。纳米药物在治疗、监测、诊断和控制各种疾病方面具有巨大的治疗诊断潜力,正吸引着难以估量的研究资源投入。在出版物数量呈指数级增长的背景下,有必要帮助读者全面了解纳米药物领域的研究活动。在此,本综述阐述了纳米药物的发展趋势、新型纳米载体、纳米药物的命运和安全性及其广泛应用。此外,还讨论了纳米药物临床转化面临的潜在挑战和障碍。对纳米药物研究趋势各方面的阐述可能有助于启发读者,并为未来的研究指明方向。