Liu Yu-Fei, Song Zhi-Min, Zeng Meng-Nan, Wang Yan-Zhi, Cheng Yong-Xian, Qiao Lin-Qing, Peng Rui, Feng Wei-Sheng
School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, 450046, PR China.
School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, 450046, PR China; Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases co-constructed by Henan province & Education Ministry of P.R. China, Zhengzhou, 450046, China.
Phytochemistry. 2022 Nov;203:113360. doi: 10.1016/j.phytochem.2022.113360. Epub 2022 Aug 13.
Eight previously undescribed diterpenoids, rosins A-H, and nine known diterpenoids were isolated from the resin from Pinus kesiya var. langbianensis (A.Chev.) Gaussen ex Bui (Pinaceae) extracted with 95% ethanol. Their structures were determined by nuclear magnetic resonance spectroscopy, mass spectrometry, J-based configuration analysis (JBCA), NOESY spectra, calculated NMR chemical shifts and electronic circular dichroic (ECD) spectra. All compounds were evaluated for their protective effects in LPS-treated human normal lung epithelial cells (BEAS-2B), and the cell viability was significantly increased after treatment with compounds 5, 10, 12, or 15 at a concentration of 10 μM.
从思茅松（Pinus kesiya var. langbianensis (A.Chev.) Gaussen ex Bui）（松科）用95%乙醇提取的树脂中分离得到8个新的二萜类化合物——松香A-H以及9个已知的二萜类化合物。通过核磁共振光谱、质谱、基于J的构型分析（JBCA）、NOESY谱、计算的核磁共振化学位移和电子圆二色（ECD）光谱确定了它们的结构。对所有化合物在脂多糖处理的人正常肺上皮细胞（BEAS-2B）中的保护作用进行了评估，在浓度为10 μM的化合物5、10、12或15处理后，细胞活力显著增加。
