School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, PR China; Co-construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan & Education Ministry of P.R. China, PR China.
School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, PR China; Co-construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan & Education Ministry of P.R. China, PR China.
Fitoterapia. 2023 Jun;167:105474. doi: 10.1016/j.fitote.2023.105474. Epub 2023 Mar 20.
Seven new diterpenoids quinones (1-6), together with five known ones (7-11), were isolated from the roots of Salvia miltiorrhiza Bunge. Their structures were elucidated by using 1D and 2D NMR data, while the relative and absolute configurations were confirmed by interpretations of the NOESY correlations and comparison of the experimental and calculated ECD spectra. In the evaluation of bioactivities, salviamilthiza C (3), significantly increased cell viability and decreased the expression of IL-1β in LPS-induced BEAS-2B cells.
从丹参的根部分离得到了 7 个新的二萜醌类化合物（1-6），以及 5 个已知的化合物（7-11）。通过 1D 和 2D NMR 数据阐明了它们的结构，而通过对 NOESY 相关谱和实验与计算 ECD 光谱的比较，确定了它们的相对和绝对构型。在生物活性评价中，丹参 C（3）显著提高了 LPS 诱导的 BEAS-2B 细胞的存活率，并降低了 IL-1β的表达。
