Laissue J A, Russi C, Altermatt H J, Truniger B
Hautarzt. 1987 Apr;38(4):232-4.
A patient suffering from a metastasizing malignant melanoma of the skin developed diffuse melanosis of the skin and melanuria a few weeks before death occurred. At autopsy, disseminated metastases of malignant melanoma were associated with marked melanosis of the organs and particularly of the mononuclear phagocytic system. In addition, neutrophilic granulocytes of the peripheral blood frequently contained melanin granules. The presence of melanin in blood monocytes and granulocytes may be useful for the diagnosis of (metastasizing) malignant melanoma.
一名患有皮肤转移性恶性黑色素瘤的患者在死亡前几周出现了皮肤弥漫性黑变病和黑尿症。尸检时，恶性黑色素瘤的播散性转移与器官尤其是单核吞噬细胞系统的明显黑变病有关。此外，外周血中性粒细胞经常含有黑色素颗粒。血液单核细胞和粒细胞中黑色素的存在可能有助于（转移性）恶性黑色素瘤的诊断。
