Eide J
Histopathology. 1981 May;5(3):285-94. doi: 10.1111/j.1365-2559.1981.tb01787.x.
A case of disseminated malignant melanoma with generalized melanosis of the skin and other tissues, melanuria, melanoptysis, and a dark brown blood serum is reported. The reticuloendothelial system contained large amounts of melanin pigment. Lysis of degenerating pigment-loaded melanoma cells in peripheral blood vessels seemed to be of considerable importance in the pigmentation of tissues. Focal pigmentation of capillary endothelium and perivascular deposition of melanin pigment in macrophages and, occasionally contained large amounts of melanin pigment. Lysis of degenerating pigment-loaded melanoma cells in peripheral blood vessels seemed to be of considerable importance in the pigmentation of tissues. Focal pigmentation of capillary endothelium and perivascular deposition of melanin pigment in macrophages and, occasionally contained large amounts of melanin pigment. Lysis of degenerating pigment-loaded melanoma cells in peripheral blood vessels seemed to be of considerable importance in the pigmentation of tissues. Focal pigmentation of capillary endothelium and perivascular deposition of melanin pigment in macrophages and, occasionally, in other cells, was noted. Single cell metastases contributed to melanin pigmentation of most organs, but were not found in sections of the skin. Melanoptysis (black sputum) was due to diffuse melanoma cell infiltration of the lungs, with secondary pigment deposition in macrophages and in bronchial epithelial cells. In this case the 'glomerular melanoma cell emboli' recorded by previous authors consisted of melanin pigment and cell debris. Focal damage of glomeruli affected by pigment emboli is described allowing access of melanoma cell debris (including melanin pigment granules) into glomerular tubules.
报告了一例播散性恶性黑色素瘤病例，伴有皮肤及其他组织的全身性黑素沉着、黑尿、黑痰以及深棕色血清。网状内皮系统含有大量黑色素。外周血管中退化的、负载色素的黑色素瘤细胞的溶解似乎在组织色素沉着中具有相当重要的意义。毛细血管内皮的局灶性色素沉着以及黑色素在巨噬细胞中血管周围的沉积，偶尔在其他细胞中也有发现，这些细胞含有大量黑色素。外周血管中退化的、负载色素的黑色素瘤细胞的溶解似乎在组织色素沉着中具有相当重要的意义。毛细血管内皮的局灶性色素沉着以及黑色素在巨噬细胞中血管周围的沉积，偶尔在其他细胞中也有发现，这些细胞含有大量黑色素。外周血管中退化的、负载色素的黑色素瘤细胞的溶解似乎在组织色素沉着中具有相当重要的意义。毛细血管内皮的局灶性色素沉着以及黑色素在巨噬细胞中血管周围的沉积，偶尔在其他细胞中也有发现。单细胞转移导致大多数器官的黑色素沉着，但在皮肤切片中未发现。黑痰是由于肺部弥漫性黑色素瘤细胞浸润，黑色素在巨噬细胞和支气管上皮细胞中继发性沉积所致。在该病例中作者之前记录的“肾小球黑色素瘤细胞栓子”由黑色素和细胞碎片组成。描述了受色素栓子影响的肾小球的局灶性损伤，使黑色素瘤细胞碎片（包括黑色素颗粒）进入肾小管。
