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口服阿仑膦酸钠治疗伴有甲状腺功能亢进的McCune-Albright综合征所致病理性股骨干骨折：一例报告

Pathological Femoral Shaft Fracture With McCune-Albright Syndrome With Hyperthyroidism Managed With Oral Alendronate: A Case Report.

作者信息

Bansal Kuldeep, Prasad Avijeet, Singh Sumedha, Chauhan Ankita, Singla Shubham

机构信息

Orthopaedics, University College of Medical Sciences, New Delhi, IND.

Radiodiagnosis, Institute of Medical Sciences and SUM Hospital, Bhubaneswar, IND.

出版信息

Cureus. 2022 Jul 13;14(7):e26802. doi: 10.7759/cureus.26802. eCollection 2022 Jul.

DOI:10.7759/cureus.26802
PMID:35971343
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9373833/
Abstract

McCune-Albright syndrome (MAS) is a complex endocrinopathy with polyostotic fibrous dysplasia and spots. Pathological femoral shaft fracture along with MAS is not a common occurrence. Bisphosphonates can be used for the management of pathological fractures. A seven-year-old male child presented with pathological femoral shaft fracture with MAS ( macules and hyperthyroidism). The patient was managed conservatively with closed reduction along with hip spica and oral alendronate. Fracture consolidation occurred within six to eight weeks with improvement in bone pains. Oral alendronate can be used as an adjuvant to conservative therapy for pathological fracture in MAS in children.

摘要

McCune-Albright综合征（MAS）是一种伴有多骨纤维发育不良和皮肤色素沉着斑的复杂内分泌病。伴有MAS的股骨干病理性骨折并不常见。双膦酸盐可用于治疗病理性骨折。一名7岁男童因MAS（有皮肤色素沉着斑和甲状腺功能亢进）出现股骨干病理性骨折。该患者接受了闭合复位、髋人字石膏固定及口服阿仑膦酸钠的保守治疗。骨折在6至8周内愈合，骨痛症状改善。口服阿仑膦酸钠可作为儿童MAS病理性骨折保守治疗的辅助用药。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c90/9373833/33aa691a70c2/cureus-0014-00000026802-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c90/9373833/4e3260686048/cureus-0014-00000026802-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c90/9373833/8e046cfc39d7/cureus-0014-00000026802-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c90/9373833/16802dff42c1/cureus-0014-00000026802-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c90/9373833/bbf8e0763d39/cureus-0014-00000026802-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c90/9373833/33aa691a70c2/cureus-0014-00000026802-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c90/9373833/4e3260686048/cureus-0014-00000026802-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c90/9373833/8e046cfc39d7/cureus-0014-00000026802-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c90/9373833/16802dff42c1/cureus-0014-00000026802-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c90/9373833/bbf8e0763d39/cureus-0014-00000026802-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c90/9373833/33aa691a70c2/cureus-0014-00000026802-i05.jpg

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本文引用的文献

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Best practice management guidelines for fibrous dysplasia/McCune-Albright syndrome: a consensus statement from the FD/MAS international consortium.纤维结构不良/ McCune-Albright 综合征最佳实践管理指南：来自 FD/MAS 国际联合会的共识声明。
Orphanet J Rare Dis. 2019 Jun 13;14(1):139. doi: 10.1186/s13023-019-1102-9.
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Treatment of shepherd's crook deformity in patients with polyostotic fibrous dysplasia using a new type of custom made retrograde intramedullary nail: a technical note.使用新型定制逆行髓内钉治疗多骨型纤维发育不良患者的牧羊拐畸形：技术说明
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Outcome of Long-Term Bisphosphonate Therapy in McCune-Albright Syndrome and Polyostotic Fibrous Dysplasia.McCune-Albright综合征和多骨型纤维性发育不良的长期双膦酸盐治疗结果
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Oral Alendronate Treatment for Severe Polyostotic Fibrous Dysplasia due to McCune-Albright Syndrome in a Child: A Case Report.口服阿仑膦酸盐治疗儿童McCune-Albright综合征所致严重多骨型纤维性骨营养不良：一例报告
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