Department of Chemistry, York University, 4700 Keele Street, Toronto, Ontario M3J 1P3, Canada.
J Org Chem. 2022 Sep 2;87(17):11457-11468. doi: 10.1021/acs.joc.2c01017. Epub 2022 Aug 16.
We report a method for the synthesis of carbamoyl fluorides from secondary amines using bench-stable, inexpensive, and readily accessible starting materials that, when combined, yield a surrogate for toxic difluorophosgene (COF) gas. In contrast to state-of-the-art methods for the synthesis of carbamoyl fluorides, our protocol does not require the use of pre-functionalized substrates, the preparation of light-, temperature-, and/or moisture-sensitive chemicals, or the application of explosive fluorinating reagents.
我们报告了一种使用稳定、廉价且易于获得的起始原料从仲胺合成碳酰胺氟化物的方法，这些起始原料组合后可以生成替代有毒二氟光气（COF）气体的物质。与合成碳酰胺氟化物的现有技术方法相比，我们的方案不需要使用预官能化的底物、制备对光、温度和/或湿度敏感的化学品、或使用爆炸氟化试剂。
