Kristensen J K
J Invest Dermatol. 1978 Oct;71(4):269-73. doi: 10.1111/1523-1747.ep12515103.
Reactive hyperemia following ischemia in cutaneous tissue of human fingers was studied in 6 normal persons and 9 patients suffering from generalized scleroderma. Ischemia lasting 6 or 12 min was induced by inflating a cuff placed around the proximal phalanx to 300 mm Hg. Blood flow was measured by the local atraumatic 133Xenon wash-out technique. The following parameters were calculated: (1) Maximum blood flow was calculated from the steepest part of the wash-out curve following release of the cuff. (2) Excess cumulative blood flow, i.e., the integrated blood flow from release of cuff until preischemic blood flow values were obtained, minus preischemic blood flow times duration of ischemia. (3) Repayment, i.e., excess cumulative blood flow in percent of preischemic blood flow times duration of ischemia. Maximum blood flow, excess cumulative blood flow and repayment was decreased in the patients compared to normals. This might be due to structural changes of the blood vessel walls and/or functional changes of the vascular smooth muscle cells in scleroderma.
对6名正常人和9名全身性硬皮病患者的人手指皮肤组织缺血后的反应性充血进行了研究。通过将置于近节指骨周围的袖带充气至300毫米汞柱来诱导持续6分钟或12分钟的缺血。采用局部无创性133氙洗脱技术测量血流量。计算了以下参数：(1) 最大血流量是根据袖带松开后洗脱曲线最陡部分计算得出的。(2) 累积过量血流量，即从袖带松开至获得缺血前血流量值的时间段内的累积血流量，减去缺血前血流量乘以缺血持续时间。(3) 偿还率，即累积过量血流量占缺血前血流量乘以缺血持续时间的百分比。与正常人相比，患者的最大血流量、累积过量血流量和偿还率均降低。这可能是由于硬皮病中血管壁的结构变化和/或血管平滑肌细胞的功能变化所致。
