Kristensen J K, Henriksen O
J Invest Dermatol. 1979 May;72(5):232-4. doi: 10.1111/1523-1747.ep12531693.
Passive distensibility of of the vascular bed in cutaneous tissue of the hand was examined in 7 normal persons and 15 patients suffering from generalized scleroderma of the acrosclerosis type. Paralysis of vascular smooth muscle cells was obtained by locally injected papaverine. Increase in vascular transmural pressure was induced by lowering the limb. Blood flow was estimated by the local Xenon wash-out technique. There was no significant difference between the patients and the normals in relative blood flow during lowering, when injection volumes of 0.005 and 0.02 ml were used, indicating that distensibility of the vascular bed in cutaneous tissue in generalized scleroderma is not diminished. However, in generalized scleroderma an injection volume of 0.1 ml caused a significant decrease in relative blood flow during lowering. This phenomenon observed in the patients probably reflects changes in total tissue pressure opposing distension of the vascular bed. This suggests an altered pressure-volume relationship of the interstitial fluid spaces in cutaneous tissue of generalized scleroderma.
在7名正常人以及15名患有肢端硬化型全身性硬皮病的患者中，对手部皮肤组织血管床的被动扩张性进行了检查。通过局部注射罂粟碱使血管平滑肌细胞麻痹。通过降低肢体来诱导血管跨壁压力增加。采用局部氙洗脱技术估计血流量。当使用0.005毫升和0.02毫升的注射量时，患者和正常人在降低肢体过程中的相对血流量没有显著差异，这表明全身性硬皮病患者皮肤组织血管床的扩张性并未降低。然而，在全身性硬皮病患者中，0.1毫升的注射量会导致降低肢体过程中相对血流量显著减少。在患者中观察到的这种现象可能反映了对抗血管床扩张的总组织压力的变化。这表明全身性硬皮病患者皮肤组织间质液间隙的压力-容积关系发生了改变。
