School of Electromechanical Engineering, Guangdong University of Technology, Guangzhou 510006, People's Republic of China.
School of Stomatology, Jinan University, Guangzhou 510632, People's Republic of China.
Colloids Surf B Biointerfaces. 2022 Oct;218:112755. doi: 10.1016/j.colsurfb.2022.112755. Epub 2022 Aug 9.
Strontium carbonate (SrC) bioceramics are proposed as potential biomaterials to efficaciously repair the bone defects. However, the development of SrC bioceramics is restricted by their intrinsic low mechanical strength. In this study, SrC-based composite bioceramics (SrC-SrP) were fabricated by incorporating strontium-containing phosphate glass (SrP). The results indicated that aside from the main crystalline phase SrC, new compounds were generated in the SrC-SrP bioceramics. Incorporating 10 wt% SrP promoted densification, thus dramatically improving compressive strength of SrC-SrP bioceramics. The SrC-SrP bioceramics facilitated apatite precipitation on their surface, and sustainedly released strontium, phosphorus and sodium ions. Compared with the well-known β-tricalcium phosphate bioceramics, the SrC-SrP bioceramics with certain amounts of SrP enhanced proliferation, alkaline phosphatase activity and osteogenesis-related gene expressions of mouse bone mesenchymal stem cells. The SrC-SrP bioceramics with appropriate constituent can serve as novel bone regenerative biomaterials.
碳酸锶（SrC）生物陶瓷被提议作为有效修复骨缺损的潜在生物材料。然而，SrC 生物陶瓷的发展受到其固有低机械强度的限制。在本研究中，通过掺入含锶磷酸盐玻璃（SrP）制备了基于 SrC 的复合生物陶瓷（SrC-SrP）。结果表明，除了主要的晶相 SrC 之外，SrC-SrP 生物陶瓷中还生成了新的化合物。掺入 10wt% SrP 促进了致密化，从而显著提高了 SrC-SrP 生物陶瓷的抗压强度。SrC-SrP 生物陶瓷促进了表面磷灰石的沉淀，并持续释放锶、磷和钠离子。与著名的 β-磷酸三钙生物陶瓷相比，具有一定量 SrP 的 SrC-SrP 生物陶瓷增强了小鼠骨髓间充质干细胞的增殖、碱性磷酸酶活性和骨生成相关基因表达。具有适当成分的 SrC-SrP 生物陶瓷可以作为新型的骨再生生物材料。
