Elanco (Shanghai) Animal Health Co., Ltd, Shanghai, China.
Hesheng Food Group Co., Ltd, Jiangsu, China.
Poult Sci. 2022 Oct;101(10):102019. doi: 10.1016/j.psj.2022.102019. Epub 2022 Jun 24.
Yellow-feathered broiler chickens generally have a longer growth cycle than white broilers and therefore face different coccidiosis challenges. General single vaccine and drug regimens struggle to prevent coccidiosis for yellow broilers. In this study, a single vaccine, and a combination of coccidiostat regimens was employed to explore the preventative and control effects of different pilot regimens on coccidiosis in yellow-feathered broilers. A total of 2,000 one day old Chinese Huang Youma female broilers were allocated into 4 experimental groups, each with 5 replicates. All birds were fed the same starter feed from Days 1 to 25, and all groups were inoculated with a vaccine on Day 4. After Day 26, the groups were then fed as follows: (1) Negative control group: basal diet + vaccine (NC); (2) NC + maduramycin (NCMD); (3) NC + narasin (NCNR); and (4) NC + salinomycin (NCSL). From Days 26 to 75, the NCNR group had a lower FCR than the other groups. The 75-d BW was higher in the NCNR group than in the NCSL group but was not significantly higher than that in the NC and NCMD groups. The growth performance followed the same trend during the whole experiment (Days 1-75). Compared to the NC group, the NCNR and NCSL groups had higher intestinal mucosa SIgA concentrations at Day 40 and Day 60 (P < 0.001); however the NCMD group had lower IgG levels at Day 40 and Day 60 (P = 0.036, P = 0.006 respectively). The combination groups had significantly reduced AKP levels and urine acid concentrations at Day 60 in comparison to those of the NC group (P = 0.004). The NCNR and NCMD groups had less severe intestinal coccidiosis lesion scores than the NC and NCSL groups in older birds. Thus, a single vaccine and/or combinations with different coccidiostats had different effects on broilers. The NCNR group showed comparatively better growth performance, blood biochemical indices, immune response, and coccidiosis lesion scores.
黄羽肉鸡的生长周期一般比白羽肉鸡长，因此面临着不同的球虫病挑战。一般的单一疫苗和药物方案难以预防黄羽肉鸡的球虫病。在这项研究中，采用了单一疫苗和几种球虫抑制剂方案，以探讨不同试验方案对黄羽肉鸡球虫病的预防和控制效果。总共将 2000 只 1 日龄的中国黄羽马氏母鸡分配到 4 个实验组，每个实验组有 5 个重复。所有的鸡在第 1 天到第 25 天都喂相同的基础饲料，所有的组都在第 4 天接种疫苗。第 26 天后，各组饲料如下：（1）阴性对照组：基础日粮+疫苗（NC）；（2）NC+马杜霉素（NCMD）；（3）NC+那拉菌素（NCNR）；（4）NC+盐霉素（NCSL）。从第 26 天到第 75 天，NCNR 组的 FCR 低于其他组。NCNR 组的 75 日龄体重高于 NCSL 组，但与 NC 和 NCMD 组相比无显著差异。整个试验期间（第 1 天到第 75 天），生长性能呈现相同的趋势。与 NC 组相比，NCNR 和 NCSL 组在第 40 天和第 60 天的肠黏膜 SIgA 浓度更高（P < 0.001）；然而，NCMD 组在第 40 天和第 60 天的 IgG 水平较低（P=0.036，P=0.006）。与 NC 组相比，联合组在第 60 天的 AKP 水平和尿液酸度显著降低（P=0.004）。在较老的鸡中，NCNR 和 NCMD 组的肠道球虫病病变评分低于 NC 和 NCSL 组。因此，单一疫苗和/或不同球虫抑制剂的组合对肉鸡有不同的效果。NCNR 组表现出较好的生长性能、血液生化指标、免疫反应和球虫病病变评分。
