Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, Japan.
Division of Human Pathology, Department of Pathology and Microbiology Nihon University School of Medicine, Japan.
Placenta. 2022 Sep;127:73-76. doi: 10.1016/j.placenta.2022.07.010. Epub 2022 Jul 19.
Although SARS-CoV-2 can infect human placental tissue, vertical transmission is rare. Therefore, the placenta may function as a barrier to inhibit viral transmission to the foetus, though the mechanisms remain unclear. In this study, we confirmed the presence of the SARS-CoV-2 genome in human placental tissue by in situ hybridization with antisense probes targeting the spike protein; tissue staining was much lower when using sense probes for the spike protein. To the best of our knowledge, this is the first evidence directly indicating inefficient viral replication in the SARS-CoV-2-infected placenta. Additional studies are required to reveal the detailed mechanisms.
虽然 SARS-CoV-2 可以感染人胎盘组织，但垂直传播很少见。因此，胎盘可能起到阻止病毒传播给胎儿的屏障作用，但具体机制尚不清楚。在这项研究中，我们通过针对刺突蛋白的反义探针的原位杂交证实了 SARS-CoV-2 基因组在人胎盘组织中的存在；当使用针对刺突蛋白的正义探针时，组织染色要低得多。据我们所知，这是直接表明 SARS-CoV-2 感染的胎盘内病毒复制效率低下的首个证据。需要进一步的研究来揭示详细的机制。
