Center for Childhood Infections and Vaccines, Children's Healthcare of Atlanta and Emory University Department of Pediatrics, Atlanta, GA, 30322, USA; Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, 30329, USA; Yerkes National Primate Research Center, Atlanta, GA, 30329, USA.
Center for Childhood Infections and Vaccines, Children's Healthcare of Atlanta and Emory University Department of Pediatrics, Atlanta, GA, 30322, USA; Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, 30329, USA; Yerkes National Primate Research Center, Atlanta, GA, 30329, USA.
Biochem Biophys Res Commun. 2021 Jan 29;538:180-186. doi: 10.1016/j.bbrc.2020.12.064. Epub 2020 Dec 24.
The COVID-19 pandemic resulting from the emergence of the coronavirus SARS-CoV-2 remains a major global health concern. Pregnant individuals are more likely to develop severe COVID-19 and a number of pregnancy complications have been observed in COVID-19 patients. To date, little is known about the impact of COVID-19 on pregnancy. In this review, we examine key aspects of pregnancy that may be impacted by COVID-19 and summarize the current literature on SARS-CoV-2 infection of the placenta and in utero vertical transmission. Furthermore, we highlight recent studies exploring the role of the maternal antibody response to SARS-CoV-2 during pregnancy and the passive transfer of maternal antibodies from mothers with COVID-19 to fetus.
由冠状病毒 SARS-CoV-2 引发的 COVID-19 大流行仍然是一个主要的全球健康关注点。孕妇更有可能患上严重的 COVID-19，并且在 COVID-19 患者中观察到了许多妊娠并发症。迄今为止，人们对 COVID-19 对妊娠的影响知之甚少。在这篇综述中，我们研究了可能受 COVID-19 影响的妊娠的关键方面，并总结了目前关于 SARS-CoV-2 感染胎盘和宫内垂直传播的文献。此外，我们还重点介绍了最近研究探索了母体对 SARS-CoV-2 的抗体反应在怀孕期间的作用，以及来自患有 COVID-19 的母亲的母体抗体向胎儿的被动转移。
