Prosty Connor, Gabrielli Sofianne, Mule Pasquale, Noorah Nuzha, Baum Sharon, Greenberger Shoshana, Ensina Luis F, Zhang Xun, Netchiporouk Elena, Ben-Shoshan Moshe
Faculty of Medicine, McGill University, Montreal, QC, Canada.
Faculty of Medicine, McGill University, Montreal, QC, Canada; Division of Pediatric Allergy and Clinical Immunology, Department of Pediatrics, McGill University Health Centre, Montreal, QC, Canada.
J Allergy Clin Immunol Pract. 2022 Dec;10(12):3293-3298.e2. doi: 10.1016/j.jaip.2022.07.037. Epub 2022 Aug 13.
Few validated tools exist to evaluate chronic urticaria (CU) control in children. Although the Urticaria Control Test (UCT) exhibits favorable clinometric properties in adult CU, it is not yet validated in children.
To evaluate the validity of the UCT for the assessment of pediatric CU.
Children presenting with CU were consecutively recruited and completed both the UCT and the Children's Dermatology Life Quality Index (CDLQI) at study entry. Using the CDLQI as an anchor, we assessed the internal consistency, convergent and known-groups validity, and screening accuracy of the UCT at study entry and at follow-up.
A total of 52 children with CU were recruited. The UCT exhibited respectable internal consistency in the evaluation of CU (Cronbach's α, 0.73; 95% CI, 0.62-0.85). UCT and CDLQI scores strongly correlated (r = -0.74; P < .01). The UCT distinguished between different strata of disease severities established by the CDLQI (P < .01). Screening accuracy of the UCT was excellent in the discrimination of poorly controlled CU (area under the curve, 0.82). An optimal cutoff of less than or equal to 10 was determined for defining poorly controlled CU (sensitivity, 95.5%; specificity, 63.3%). Data at follow-up were consistent with data at study entry. Subgroup analyses of patients with chronic spontaneous urticaria were consistent with overall estimates of validity.
The UCT is a valid tool for the assessment of pediatric CU and chronic spontaneous urticaria, as evidenced by the acceptable internal consistency, convergent and known-groups validity, and screening accuracy at multiple time points.
用于评估儿童慢性荨麻疹（CU）控制情况的经过验证的工具很少。尽管荨麻疹控制测试（UCT）在成人CU中表现出良好的临床测量特性，但尚未在儿童中得到验证。
评估UCT在评估儿童CU方面的有效性。
连续招募患有CU的儿童，并在研究开始时完成UCT和儿童皮肤病生活质量指数（CDLQI）。以CDLQI为参照，我们在研究开始时和随访时评估了UCT的内部一致性、收敛效度和已知组效度以及筛查准确性。
共招募了52名患有CU的儿童。UCT在评估CU时表现出可观的内部一致性（Cronbach's α，0.73；95% CI，0.62 - 0.85）。UCT和CDLQI得分高度相关（r = -0.74；P <.01）。UCT能够区分由CDLQI确定的不同疾病严重程度分层（P <.01）。UCT在区分控制不佳的CU方面筛查准确性极佳（曲线下面积，0.82）。确定定义控制不佳的CU的最佳临界值为小于或等于10（敏感性，95.5%；特异性，63.3%）。随访数据与研究开始时的数据一致。慢性自发性荨麻疹患者的亚组分析与有效性的总体评估一致。
UCT是评估儿童CU和慢性自发性荨麻疹的有效工具，在多个时间点的可接受的内部一致性、收敛效度和已知组效度以及筛查准确性证明了这一点。
