School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Biosci Biotechnol Biochem. 2022 Sep 23;86(10):1343-1348. doi: 10.1093/bbb/zbac137.
One new compound and 13 known compounds were isolated from Aspergillus niger, a plant endophytic fungus of Pachysandra terminalis collected from Qinling Mountains, Xi'an, China. The structure of new compound 1 was classically determined by extensive spectroscopic analysis. Compounds 5, 6, 8, and 14 were first reported from Aspergillus, while compound 2 was isolated from A. niger for the first time. All isolated compounds were further evaluated for their antioxidant and α-glucosidase inhibitory activities. Compounds 2 and 3 exhibited significant antioxidant activities with IC50 values of 31.64 μm and 24.32 μm, respectively, similar to the positive control ascorbic acid. Additionally, compound 1 displayed remarkable inhibitory activity against α-glucosidase with an IC50 value of 96.25 μm, which was 3.4-fold more potent than that of the positive control acarbose. Compound 1 has great potential for development as a new lead compound owing to its simple structure and remarkable biological activity.
从中国西安秦岭地区内生植物垂序商陆的植物内生真菌黑曲霉中分离得到 1 个新化合物和 13 个已知化合物。新化合物 1 的结构通过广泛的光谱分析经典确定。化合物 5、6、8 和 14 首次从曲霉属中报道，而化合物 2 则是首次从黑曲霉中分离得到。所有分离得到的化合物均进一步评估了其抗氧化和α-葡萄糖苷酶抑制活性。化合物 2 和 3 表现出显著的抗氧化活性，IC50 值分别为 31.64 μm 和 24.32 μm，与阳性对照抗坏血酸相当。此外，化合物 1 对α-葡萄糖苷酶表现出显著的抑制活性，IC50 值为 96.25 μm，比阳性对照阿卡波糖强 3.4 倍。化合物 1 具有作为新型先导化合物的巨大潜力，因为它具有简单的结构和显著的生物活性。
