Liu Wan, Liu Yu, Yang Fan, Han Shouye, Zhang Jia, Yang Hui, Cheng Zhongbin, Li Qin
School of Pharmacy, Henan University, Kaifeng 475004, China.
Eucommia Ulmoides Cultivation and Utilization of Henan Engineering Laboratory, Kaifeng 475004, China.
Molecules. 2021 Jun 9;26(12):3514. doi: 10.3390/molecules26123514.
The fungus strain DZ-3 was isolated from twigs of the well-known medicinal plant Oliver and identified as . Two new alkaloids, named asperflaloids A and B ( and ), together with 10 known compounds (-) were obtained from the EtOAc extract of the strain. Interestingly, the alkaloids - with different frameworks are characterized by the presence of the same anthranilic acid residue. The structures were established by detailed analyses of the spectroscopic data. The absolute configuration of asperflaloids A and B was resolved by quantum chemistry calculation. All compounds were screened for their inhibitions against α-glucosidase and the antioxidant capacities. The results were that compound had an IC value of 750.8 μM toward α-glucosidase, and the phenol compounds and exhibited potent antioxidant capacities with IC values 14.4 and 27.1 μM respectively.
真菌菌株DZ - 3是从著名药用植物[此处Oliver可能有误，未明确具体植物名称]的嫩枝中分离得到，并被鉴定为[此处未提及具体鉴定结果]。从该菌株的乙酸乙酯提取物中获得了两种新生物碱，命名为曲霉黄酮A和B（[此处未给出具体化学式]），以及10种已知化合物（[此处未给出具体化合物信息]）。有趣的是，具有不同骨架的生物碱[此处未明确具体生物碱]的特征是存在相同的邻氨基苯甲酸残基。通过对光谱数据的详细分析确定了结构。通过量子化学计算解析了曲霉黄酮A和B的绝对构型。对所有化合物进行了α - 葡萄糖苷酶抑制作用和抗氧化能力的筛选。结果表明，化合物[此处未明确具体化合物]对α - 葡萄糖苷酶的IC值为750.8 μM，酚类化合物[此处未明确具体化合物]和[此处未明确具体化合物]表现出较强的抗氧化能力，IC值分别为14.4和27.1 μM。
