Sun Zhe, Liu Lu, Liu Hongbing, Luo Fang
Department of Day Surgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, People's Republic of China.
Department of Pain Management, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, People's Republic of China.
J Pain Res. 2022 Aug 10;15:2303-2313. doi: 10.2147/JPR.S375257. eCollection 2022.
To further evaluate the effects of gasserian ganglion block treatment with local anesthetics and steroids on patients with acute/subacute zoster-related trigeminal neuralgia.
This is a multicenteric retrospective study which included patients between the ages of 26-92 years, who suffered from acute/subacute zoster-related trigeminal neuralgia and had undergone CT-guided gasserian ganglion block. The medical records of these patients between January 13, 2016 and August 25, 2021 were retrieved, and the patients were followed up for 6 months. Follow-up outcomes were Numerical Rating Scale (NRS) scores, medications and dosage. The effective rate was defined as the number of cases with NRS score reduction of >50%/total number of cases×100% at 12 weeks postoperatively.
The postoperative NRS scores were significantly decreased in all patients (P < 0.05), and NRS scores in acute zoster group were lower than those in subacute zoster group at different time points (P < 0.05). The percentage of patients who had a reduction of medication use value of >50% was 56.4% and the effective rate was 66.7% in all patients, at 3 months after the block treatment. There was no significant difference in the reduction of medication use value of >50% and the effective rates between the two groups. There were no intracranial hemorrhage, infection or other serious adverse effects in either groups.
CT-guided gasserian ganglion block with local anesthetics and steroids can be an effective and safe technique to relieve the pain of acute/subacute zoster-related trigeminal neuralgia.
进一步评估使用局部麻醉剂和类固醇进行半月神经节阻滞治疗急性/亚急性带状疱疹相关性三叉神经痛患者的效果。
这是一项多中心回顾性研究，纳入了年龄在26至92岁之间、患有急性/亚急性带状疱疹相关性三叉神经痛且接受了CT引导下半月神经节阻滞的患者。检索了这些患者在2016年1月13日至2021年8月25日期间的病历，并对患者进行了6个月的随访。随访结果包括数字评定量表（NRS）评分、用药情况及剂量。有效率定义为术后12周时NRS评分降低>50%的病例数/总病例数×100%。
所有患者术后NRS评分均显著降低（P<0.05），急性带状疱疹组在不同时间点的NRS评分均低于亚急性带状疱疹组（P<0.05）。在阻滞治疗后3个月时，所有患者中药物使用值降低>50%的患者比例为56.4%，有效率为66.7%。两组之间药物使用值降低>50%的比例及有效率无显著差异。两组均未发生颅内出血、感染或其他严重不良反应。
CT引导下使用局部麻醉剂和类固醇进行半月神经节阻滞可以是一种有效且安全的缓解急性/亚急性带状疱疹相关性三叉神经痛疼痛的技术。
