Department of Pediatrics, Medical University of South Carolina, Columbia, South Carolina.
Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado.
J Clin Sleep Med. 2022 Dec 1;18(12):2845-2853. doi: 10.5664/jcsm.10240.
This study evaluated sleep quality in relation to pain and pain-related impairment in adolescents and young adults with sickle cell disease. The purpose was to examine whether increased age was associated with poorer sleep quality and pain and to examine the sleep quality-pain association in this age group.
Eighty-nine adolescents and young adults with sickle cell disease between the ages of 13 and 25 completed ratings of sleep quality, overall pain, and 2 measures of pain-related impairment (pain impact and pain burden) as part of their clinical care. Retrospective chart reviews were completed to match ratings to demographic and medical characteristics. Correlations and multiple regression were used to examine associations between age, sleep quality, and pain variables, including an exploratory analysis of the sleep-pain association by age.
Increased age was associated with poorer sleep quality, worse overall pain, and higher pain burden. Poorer sleep quality was also associated with worse overall pain and pain burden. Using multiple regression, a small, but not statistically significant trend was observed for the interaction of increased age and strengthening of the sleep quality-pain burden association.
Sleep quality and pain are important challenges for adolescents and young adults with sickle cell disease that may persist or worsen with increased age. Early identification of these difficulties in pediatric populations as well as continued screening and intervention as adolescents transition into adult care is important. Additional longitudinal research is needed to better understand the progression of the sleep-pain relationship over time.
Schlenz AM, Thomas SJ, Gloston G, Lebensburger J, Maxwell SL, Kanter J. Sleep quality and pain in adolescents and young adults with sickle cell disease. . 2022;18(12):2845-2853.
本研究评估了与疼痛和疼痛相关障碍有关的睡眠质量在镰状细胞病青少年和年轻人中的表现。目的是检验年龄增长是否与睡眠质量和疼痛恶化相关，并在该年龄组中检验睡眠质量与疼痛的相关性。
89 名年龄在 13 至 25 岁之间的镰状细胞病青少年和年轻人作为其临床护理的一部分，完成了睡眠质量、整体疼痛以及 2 项与疼痛相关的障碍（疼痛影响和疼痛负担）的评分。完成了回顾性图表审查以将评分与人口统计学和医学特征相匹配。相关性和多元回归用于检验年龄、睡眠质量和疼痛变量之间的关联，包括对年龄分组的睡眠与疼痛的关联进行探索性分析。
年龄增长与睡眠质量较差、整体疼痛更严重和疼痛负担更高相关。较差的睡眠质量也与整体疼痛和疼痛负担更严重相关。使用多元回归，观察到年龄增长和睡眠质量与疼痛负担关联增强之间的交互作用存在一个小但无统计学意义的趋势。
睡眠质量和疼痛是镰状细胞病青少年和年轻人面临的重要挑战，随着年龄增长，这些问题可能持续或恶化。在儿科人群中早期识别这些困难，以及青少年过渡到成人护理时持续进行筛查和干预非常重要。需要进一步的纵向研究来更好地了解随着时间推移睡眠与疼痛关系的进展。
Schlenz AM, Thomas SJ, Gloston G, Lebensburger J, Maxwell SL, Kanter J. Sleep quality and pain in adolescents and young adults with sickle cell disease.. 2022;18(12):2845-2853.
