Ameringer Suzanne, Elswick R K, Smith Wally
1Virginia Commonwealth University, Richmond, VA, USA.
J Pediatr Oncol Nurs. 2014 Jan-Feb;31(1):6-17. doi: 10.1177/1043454213514632. Epub 2013 Dec 30.
This descriptive, correlational study examined fatigue and potential biological and behavioral correlates in adolescents and young adults with sickle cell disease. Sixty adolescents and young adults with sickle cell disease completed the Brief Fatigue Inventory, Multidimensional Fatigue Symptom Inventory-Short Form, Patient Reported Outcomes Measurement Information System (PROMIS) fatigue short form and measures of pain, sleep quality, anxiety, depressive mood, stress, disease severity, and quality of life. Blood samples were obtained for hemoglobin and cytokines. Fatigue scores were mostly moderate in severity. Fatigue interfered to a moderate degree with daily activities and correlated significantly with pain, sleep quality, state and trait anxiety, depressive mood, stress, and quality of life. Fatigue was correlated with hemoglobin on the PROMIS measure. Fatigue was not correlated with cytokines or age, nor differed by disease severity. Fatigue was common in these adolescents and young adults, interfered with daily activities such as school, work and exercise, and significantly correlated with several potentially modifiable factors. As life expectancy increases in sickle cell disease, research is needed to test interventions to reduce fatigue.
这项描述性、相关性研究调查了患有镰状细胞病的青少年和青年的疲劳状况以及潜在的生物学和行为学相关因素。60名患有镰状细胞病的青少年和青年完成了简明疲劳量表、多维疲劳症状量表简表、患者报告结局测量信息系统（PROMIS）疲劳简表以及疼痛、睡眠质量、焦虑、抑郁情绪、压力、疾病严重程度和生活质量的测量。采集血样以检测血红蛋白和细胞因子。疲劳评分大多为中度严重程度。疲劳对日常活动有中度干扰，且与疼痛、睡眠质量、状态焦虑和特质焦虑、抑郁情绪、压力及生活质量显著相关。在PROMIS测量中，疲劳与血红蛋白相关。疲劳与细胞因子或年龄无关，也不因疾病严重程度而有差异。疲劳在这些青少年和青年中很常见，会干扰学校、工作和锻炼等日常活动，并且与几个可能可改变的因素显著相关。随着镰状细胞病患者预期寿命的增加，需要开展研究来测试减轻疲劳的干预措施。
