Kuloğlu Ersin, Albayrak Bülent, Dursun Hakan, Albayrak Fatih, Yılmaz Ömer
Department of Internal Medicine, Atatürk University Faculty of Medicine, Erzurum, Turkey.
Department of Gastroentorology, Atatürk University Faculty of Medicine, Erzurum, Turkey.
Eurasian J Med. 2022 Oct;54(3):235-238. doi: 10.5152/eurasianjmed.2022.20360.
Many treatment protocols are used in Helicobacter pylori eradication treatment within the framework of factors such as antibiotic resistance, drug side effects, patient compliance, and regional differences.
H. pylori was diagnosed with upper gastrointestinal system endoscopic biopsy in the Internal Diseases Gastroenterology Endoscopy Unit of Atatürk University Medical Faculty Hospital; a total of 229 patients over the age of 18 were evaluated prospectively by dividing them into 3 groups and applying 3 different H. pylori eradication treatment protocols.
A total of 229 patients who completed the treatment were included in the study. H. pylori eradication was achieved in 186 patients and not achieved in 43 patients. The H. pylori eradication success of our study was found to be 81.2%. Among the 84 patients in group 1, while H. pylori eradication was achieved in 67 of them, it was not achieved in 17 patients. The eradication success of quadruple treatment with bismuth was 79.8%. Also, among the 68 patients in group 2, while H. pylori eradication was achieved in 55 patients, it was not achieved in 13. The eradication success of the 14-day hybrid treatment was 80.9%. Among the 77 patients in group 3, while H. pylori eradication was achieved in 64 patients, it was not achieved in 13. The eradication success of the 10-day sequential treatment was 83.1%.
It is necessary to conduct studies to find the most successful eradication regimen in primary care treatment of H. pylori in our country, to determine the regional antibiotic resistance rates, to individualize the proton pump inhibitor treatment due to metabolism and resistance differences, to examine the factors that stop from achieving the desired eradication success, and especially to avoid unnecessary antibiotic use.
在抗生素耐药性、药物副作用、患者依从性和地区差异等因素的框架内，许多治疗方案被用于幽门螺杆菌根除治疗。
在阿塔图尔克大学医学院医院内科胃肠病学内镜科，通过上消化道系统内镜活检诊断幽门螺杆菌；将18岁以上的229例患者前瞻性地分为3组，应用3种不同的幽门螺杆菌根除治疗方案进行评估。
共有229例完成治疗的患者纳入研究。186例患者实现了幽门螺杆菌根除，43例未实现。研究发现幽门螺杆菌根除成功率为81.2%。在第1组的84例患者中，67例实现了幽门螺杆菌根除，17例未实现。铋剂四联疗法的根除成功率为79.8%。此外，在第2组的68例患者中，55例实现了幽门螺杆菌根除，13例未实现。14天混合疗法的根除成功率为80.9%。在第3组的77例患者中，64例实现了幽门螺杆菌根除，13例未实现。10天序贯疗法的根除成功率为83.1%。
有必要开展研究，以找到我国基层医疗中幽门螺杆菌最成功的根除方案，确定地区抗生素耐药率，因代谢和耐药差异使质子泵抑制剂治疗个体化，检查阻碍实现预期根除成功率的因素，尤其是避免不必要的抗生素使用。
