用于儿童 COVID-19 初步诊断的基线实验室参数：一项横断面研究。
Baseline laboratory parameters for preliminary diagnosis of COVID-19 among children: a cross-sectional study.
机构信息
MD. Clinical Biochemistry Resident and Teaching Assistant, Department of Biochemistry, Medical Faculty, University of Novi Sad, Serbia; and Physician, Department of Laboratory Diagnostics, Institute for Child and Youth Health Care of Vojvodina, Novi Sad, Serbia.
MD, PhD. Medical Biochemist, Department of Laboratory Diagnostics, Institute for Child and Youth Health Care of Vojvodina, Novi Sad, Serbia; and Assistant Professor, Department of Biochemistry, Medical Faculty, University of Novi Sad, Serbia.
出版信息
Sao Paulo Med J. 2022 Sep-Oct;140(5):691-696. doi: 10.1590/1516-3180.2021.0634.R1.05012022.
BACKGROUND
Clinical judgment of initial baseline laboratory tests plays an important role in triage and preliminary diagnosis among coronavirus disease 2019 (COVID-19) patients.
OBJECTIVES
To determine the differences in laboratory parameters between COVID-19 and COVID-like patients, and between COVID-19 and healthy children. Additionally, to ascertain whether healthy children or patients with COVID-like symptoms would form a better control group.
DESIGN AND SETTING
Cross-sectional study at the Institute for Child and Youth Health Care of Vojvodina, Novi Sad, Serbia.
METHODS
A retrospective study was conducted on 42 pediatric patients of both sexes with COVID-19. Hematological parameters (white blood cell count, absolute lymphocyte count and platelet count) and biochemical parameters (natremia, kalemia, chloremia, aspartate aminotransferase [AST], alanine aminotransferase [ALT], lactate dehydrogenase [LDH] and C-reactive protein [CRP]) were collected. The first control group was formed by 80 healthy children and the second control group was formed by 55 pediatric patients with COVID-like symptoms.
RESULTS
Leukocytosis, lymphopenia, thrombocytosis, elevated systemic inflammatory index and neutrophil-lymphocyte ratio, hyponatremia, hypochloremia and elevated levels of AST, ALT, LDH and CRP were present in COVID patients, in comparison with healthy controls, while in comparison with COVID-like controls only lymphopenia was determined.
CONCLUSIONS
The presence of leukocytosis, lymphopenia, thrombocytosis, elevated systemic inflammatory index and neutrophil-lymphocyte ratio, hyponatremia, hypochloremia and elevated levels of AST, ALT, LDH and CRP may help healthcare providers in early identification of COVID-19 patients. Healthy controls were superior to COVID-like controls since they provided better insight into the laboratory characteristics of children with novel betacoronavirus (SARS-CoV-2) infection.
背景
在 2019 冠状病毒病（COVID-19）患者的分诊和初步诊断中，临床医生对初始基线实验室检测的判断起着重要作用。
目的
确定 COVID-19 患者与 COVID 样患者以及 COVID-19 患者与健康儿童之间实验室参数的差异。此外，确定健康儿童或具有 COVID 样症状的患者是否会形成更好的对照组。
设计和设置
塞尔维亚诺维萨德伏伊伏丁那儿童和青少年保健研究所的横断面研究。
方法
对 42 名患有 COVID-19 的男女儿童患者进行回顾性研究。收集了血液学参数（白细胞计数、绝对淋巴细胞计数和血小板计数）和生化参数（血钠、血钾、血氯、天门冬氨酸氨基转移酶[AST]、丙氨酸氨基转移酶[ALT]、乳酸脱氢酶[LDH]和 C 反应蛋白[CRP]）。第一个对照组由 80 名健康儿童组成，第二个对照组由 55 名患有 COVID 样症状的儿科患者组成。
结果
与健康对照组相比，COVID 患者存在白细胞增多、淋巴细胞减少、血小板增多、全身性炎症指数和中性粒细胞-淋巴细胞比值升高、低钠血症、低氯血症以及 AST、ALT、LDH 和 CRP 水平升高，而与 COVID 样对照组相比，仅存在淋巴细胞减少。
结论
白细胞增多、淋巴细胞减少、血小板增多、全身性炎症指数和中性粒细胞-淋巴细胞比值升高、低钠血症、低氯血症以及 AST、ALT、LDH 和 CRP 水平升高可能有助于医疗保健提供者早期识别 COVID-19 患者。与 COVID 样对照组相比，健康对照组具有优势，因为它们提供了对新型贝塔冠状病毒（SARS-CoV-2）感染儿童实验室特征的更好了解。
Zotero 插件