Leaverton P E, Sorlie P D, Kleinman J C, Dannenberg A L, Ingster-Moore L, Kannel W B, Cornoni-Huntley J C
J Chronic Dis. 1987;40(8):775-84. doi: 10.1016/0021-9681(87)90129-9.
The Framingham Heart Study has been the foundation upon which several national policies regarding risk factors for coronary heart disease mortality are based. The NHANES I Epidemiologic Followup Study is the first national cohort study based upon a comprehensive medical examination of a probability sample of United States adults. The average follow-up time was 10 years. This study afforded an opportunity to evaluate the generalizability of the Framingham risk model, using systolic blood pressure, total cholesterol, and cigarette smoking, to the U.S. population with respect to predicting death from coronary heart disease. The Framingham model predicts remarkably well for this national sample. The major risk factors for coronary heart disease mortality described in previous Framingham analyses are applicable to the United States white adult population.
弗雷明汉心脏研究一直是多项关于冠心病死亡率风险因素的国家政策的基础。美国国家健康和营养检查调查（NHANES I）流行病学随访研究是第一项基于对美国成年人概率样本进行全面医学检查的全国性队列研究。平均随访时间为10年。这项研究提供了一个机会，以评估弗雷明汉风险模型（使用收缩压、总胆固醇和吸烟情况）在美国人群中预测冠心病死亡的可推广性。弗雷明汉模型对这个全国性样本的预测效果非常好。先前弗雷明汉分析中描述的冠心病死亡率的主要风险因素适用于美国白人成年人群体。
