Huang Gary, Dierick Herman A
Department of Molecular & Human Genetics, Baylor College of Medicine, Houston, TX, United States.
Department of Neuroscience, Baylor College of Medicine, Houston, TX, United States.
Front Behav Neurosci. 2022 Aug 1;16:901453. doi: 10.3389/fnbeh.2022.901453. eCollection 2022.
Aggression is an evolutionarily conserved behavior present in most animals and is necessary for survival when competing for limited resources and mating partners. Studies have shown that aggression is modulated both genetically and epigenetically, but details of how the molecular and cellular mechanisms interact to determine aggressive behavior remain to be elucidated. In recent decades, has emerged as a powerful model system to understand the mechanisms that regulate aggression. Surprisingly most of the findings discovered to date have not come from genetic screens despite the fly's long and successful history of using screens to unravel its biology. Here, we highlight the tools and techniques used to successfully screen for aggression-linked behavioral elements in and discuss the potential impact future screens have in advancing our knowledge of the underlying genetic and neural circuits governing aggression.
攻击行为是大多数动物中一种进化上保守的行为，在争夺有限资源和交配伙伴时对于生存至关重要。研究表明，攻击行为受到基因和表观遗传的调节，但分子和细胞机制如何相互作用以决定攻击行为的细节仍有待阐明。近几十年来，果蝇已成为理解调节攻击行为机制的强大模型系统。令人惊讶的是，尽管果蝇在利用筛选来揭示其生物学特性方面有着悠久且成功的历史，但迄今为止发现的大多数结果并非来自基因筛选。在这里，我们重点介绍用于成功筛选果蝇中与攻击行为相关的行为要素的工具和技术，并讨论未来筛选在推进我们对控制攻击行为的潜在遗传和神经回路的认识方面的潜在影响。
