Hu Ce-Gui, Hu Bai-E, Zhu Jin-Feng, Zhu Zheng-Ming, Huang Chao
Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China.
World J Gastrointest Surg. 2022 Jun 27;14(6):580-593. doi: 10.4240/wjgs.v14.i6.580.
Hemoglobin and albumin are associated with the prognosis of gastric cancer (GC) patients. However, the prognostic value of the hemoglobin to albumin ratio (HAR) for the short-term survival of GC patients with D2 radical resection has not been studied.
To investigate the significance of the HAR in evaluating the short-term survival of GC patients after D2 radical resection and to construct a nomogram to predict the prognosis in GC patients after surgery, thus providing a reference for the development of postoperative individualized treatment and follow-up plans.
Cox regression and Kaplan-Meier analysis was used for prognostic analysis. Logistic regression was used to analyze the relationships between HAR and the clinicopathological characteristics of the GC patients. A prognostic nomogram model for the short-term survival of GC patients was constructed by R software.
HAR was an independent risk factor for the short-term survival of GC patients. GC patients with a low HAR had a poor prognosis ( < 0.001). Low HAR was markedly related to high stage [odds ratio (OR) = 0.45 for II I; OR = 0.48 for III I], T classification (OR = 0.52 for T4 T1) and large tumor size (OR = 0.51 for ≥ 4 cm < 4 cm) (all < 0.05). The nomogram model was based on HAR, age, CA19-9, CA125 and stage, and the C-index was 0.820.
Preoperative low HAR was associated with short-term survival in GC patients. The prognostic nomogram model can accurately predict the short-term survival of GC patients with D2 radical resection.
血红蛋白和白蛋白与胃癌（GC）患者的预后相关。然而，血红蛋白与白蛋白比值（HAR）对接受D2根治性切除术的GC患者短期生存的预后价值尚未得到研究。
探讨HAR在评估D2根治性切除术后GC患者短期生存中的意义，并构建列线图预测GC患者术后的预后，从而为制定术后个体化治疗和随访计划提供参考。
采用Cox回归和Kaplan-Meier分析进行预后分析。采用Logistic回归分析HAR与GC患者临床病理特征之间的关系。通过R软件构建GC患者短期生存的预后列线图模型。
HAR是GC患者短期生存的独立危险因素。HAR低的GC患者预后较差（<0.001）。低HAR与高分期[II期对I期的优势比（OR）=0.45；III期对I期的OR = 0.48]、T分类（T4对T1的OR = 0.52）和肿瘤大尺寸（≥4 cm对<4 cm的OR = 0.51）显著相关（均<0.05）。列线图模型基于HAR、年龄、CA19-9、CA125和分期，C指数为0.820。
术前低HAR与GC患者的短期生存相关。预后列线图模型可准确预测接受D2根治性切除术的GC患者的短期生存。
