Department of Oncology, Ganyu District People's Hospital of Lianyungang City, Lianyungang, China.
Institute of Molecular Biology and Translational Medicine, The Affiliated People's Hospital, Jiangsu University, Zhenjiang, China.
Front Endocrinol (Lausanne). 2022 Aug 1;13:921159. doi: 10.3389/fendo.2022.921159. eCollection 2022.
To determine the impact of preexisting diabetes mellitus on cardiovascular and all-cause mortality in patients with atrial fibrillation (AF) by conducting a meta-analysis.
PubMed and Embase databases were comprehensively searched for relevant studies publishing until May 19, 2022. Cohort studies or post-hoc analyses of clinical trials that investigated the association of diabetes mellitus with cardiovascular or all-cause mortality in AF patients were included.
A total of 21 studies with 526,136 AF patients were identified. The pooled prevalence of diabetes mellitus in patients with AF was 26%. The summary multivariable-adjusted risk ratio (RR) of all-cause mortality was 1.37 (95% confidence intervals [CIs] 1.23-1.53) for patients with diabetes versus those without diabetes. Moreover, diabetes mellitus was also associated with an increased risk of cardiovascular mortality (RR 1.46; 95% CI 1.34-1.58). Stratified analyses suggested that the impact of diabetes on all-cause and cardiovascular mortality was consistently observed in each named subgroup.
The presence of diabetes mellitus in patients with AF is associated with an increased risk of cardiovascular and all-cause mortality, even after adjustment for important confounding factors.
通过荟萃分析，确定糖尿病对房颤（AF）患者心血管和全因死亡率的影响。
全面检索了 PubMed 和 Embase 数据库，以获取截至 2022 年 5 月 19 日发表的相关研究。纳入了研究糖尿病与 AF 患者心血管或全因死亡率之间关联的队列研究或临床试验的事后分析。
共确定了 21 项研究，涉及 526136 名 AF 患者。AF 患者中糖尿病的总体患病率为 26%。与无糖尿病患者相比，糖尿病患者的全因死亡率的汇总多变量调整风险比（RR）为 1.37（95%置信区间[CI]1.23-1.53）。此外，糖尿病也与心血管死亡率增加相关（RR 1.46；95%CI 1.34-1.58）。分层分析表明，糖尿病对全因和心血管死亡率的影响在每个指定的亚组中均一致观察到。
即使在调整了重要的混杂因素后，AF 患者的糖尿病存在与心血管和全因死亡率的增加风险相关。
