Asao Tetsuhiko, Tobias Gabriel Cardial, Lucotti Serena, Jones David R, Matei Irina, Lyden David
Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, Cell & Developmental Biology, Drukier Institute for Children's Health and Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10021, USA.
Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Extracell Vesicles Circ Nucl Acids. 2023 Sep;4(3):461-485. doi: 10.20517/evcna.2023.37. Epub 2023 Aug 16.
Over the past decade, extracellular vesicles and particles (EVPs) have emerged as critical mediators of intercellular communication, participating in numerous physiological and pathological processes. In the context of cancer, EVPs exert local effects, such as increased invasiveness, motility, and reprogramming of tumor stroma, as well as systemic effects, including pre-metastatic niche formation, determining organotropism, promoting metastasis and altering the homeostasis of various organs and systems, such as the liver, muscle, and circulatory system. This review provides an overview of the critical advances in EVP research during the past decade, highlighting the heterogeneity of EVPs, their roles in intercellular communication, cancer progression, and metastasis. Moreover, the clinical potential of systemic EVPs as useful cancer biomarkers and therapeutic agents is explored. Last but not least, the progress in EVP analysis technologies that have facilitated these discoveries is discussed, which may further propel EVP research in the future.
在过去十年中，细胞外囊泡和颗粒（EVP）已成为细胞间通讯的关键介质，参与众多生理和病理过程。在癌症背景下，EVP发挥局部作用，如增加肿瘤侵袭性、迁移能力以及对肿瘤基质进行重编程，还发挥全身作用，包括形成前转移微环境、决定器官趋向性、促进转移以及改变肝脏、肌肉和循环系统等各种器官和系统的稳态。本综述概述了过去十年EVP研究的关键进展，强调了EVP的异质性、它们在细胞间通讯、癌症进展和转移中的作用。此外，还探讨了全身性EVP作为有用的癌症生物标志物和治疗剂的临床潜力。最后但同样重要的是，讨论了促进这些发现的EVP分析技术的进展，这可能在未来进一步推动EVP研究。
