Large Animal Technical Services Team, Nippon Zenyaku Kogyo Tokyo Branch Office, Tokyo, Japan.
School of Veterinary Medicine, Rakuno Gakuen University, Hokkaido, Japan.
J Vet Med Sci. 2022 Sep 21;84(10):1335-1339. doi: 10.1292/jvms.22-0289. Epub 2022 Aug 17.
The present study aimed to clarify the alkalizing ability of 1.35% isotonic sodium bicarbonate solution (ISBS), which did not contain dextrose, compared with that of 1.35% isotonic bicarbonate sodium solution containing 4.03% dextrose (ISBD) in healthy calves. The calves were intravenously administered with 20.7 mL/kg of the solutions for 30 min as the volume required to correct base deficit of 10 mM. ISBS increased the blood pH, HCO, and base excess from 7.44 ± 0.02, 29.6 ± 1.9 mM, and 5.3 ± 2.1 mM to 7.49 ± 0.02, 36.9 ± 2.3 mM, and 13.5 ± 2.6 mM respectively (P<0.05). These factors for the ISBD group increased from 7.41 ± 0.02, 29.0 ± 1.1 mM, and 4.5 ± 1.3 mM to 7.43 ± 0.02, 33.5 ± 1.9 mM, and 9.5 ± 1.7 mM (P<0.05), respectively. Furthermore, in the ISBD group, the relative plasma volume and blood glucose level increased while the K level decreased, which did not occur in the ISBS group. Therefore, the results revealed that ISBS had better alkalizing ability in calves than ISBD.
本研究旨在阐明不含葡萄糖的 1.35%等渗碳酸氢钠溶液（ISBS）与含有 4.03%葡萄糖的 1.35%等渗碳酸氢钠溶液（ISBD）相比，在健康犊牛中的碱化能力。犊牛静脉内给予 20.7 mL/kg 的溶液 30 分钟，以纠正 10 mM 的基础缺陷所需的体积。ISBS 将血液 pH 值、HCO3- 和碱剩余从 7.44 ± 0.02、29.6 ± 1.9 mM 和 5.3 ± 2.1 mM 分别提高到 7.49 ± 0.02、36.9 ± 2.3 mM 和 13.5 ± 2.6 mM（P<0.05）。ISBD 组的这些因素从 7.41 ± 0.02、29.0 ± 1.1 mM 和 4.5 ± 1.3 mM 分别增加到 7.43 ± 0.02、33.5 ± 1.9 mM 和 9.5 ± 1.7 mM（P<0.05）。此外，在 ISBD 组中，相对血浆体积和血糖水平增加，而 K 水平降低，而在 ISBS 组中则没有发生这些情况。因此，结果表明 ISBS 在犊牛中的碱化能力优于 ISBD。
