Division of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Division of Gastroenterology, Tianyou Hospital, Wuhan University of Science and Technology, Wuhan, China.
Int J Dev Biol. 2022;66(4-5-6):333-347. doi: 10.1387/ijdb.220072fj.
Intraflagellar transport (IFT) is an essential condition for ciliogenesis. The primary cilia protrude like antennae and act as chemical or mechanical sensory organelles that coordinate specific receptor localization and signal transduction. IFT20 is the smallest molecule in IFT complex B, which is located in both the cilia and the Golgi complex. Recent studies have shown that IFT20 is a key molecule in multiple signaling pathways. Importantly, in the function of IFT20, signal transduction is not restricted to cilia, but is also involved in non-ciliary functions. Here we summarize current knowledge regarding IFT20-mediated signaling pathways and their relationship with cell development and tissue homeostasis, and analyse the cilia-dependent and cilia-independent mechanisms of IFT20 coordinated signaling pathways and potential crosstalk between the mechanisms. This review provides a comprehensive perspective on IFT20 coordinates signaling mechanisms in cell development and tissue homeostasis.
鞭毛内运输（IFT）是纤毛发生的必要条件。初级纤毛像天线一样伸出，充当化学或机械感觉细胞器，协调特定受体的定位和信号转导。IFT20 是 IFT 复合物 B 中最小的分子，存在于纤毛和高尔基体复合物中。最近的研究表明，IFT20 是多种信号通路的关键分子。重要的是，在 IFT20 的功能中，信号转导不仅限于纤毛，还涉及非纤毛功能。在这里，我们总结了目前关于 IFT20 介导的信号通路及其与细胞发育和组织稳态的关系的知识，并分析了 IFT20 协调信号通路的依赖纤毛和非依赖纤毛机制以及机制之间的潜在串扰。本综述提供了一个关于 IFT20 协调细胞发育和组织稳态中信号机制的全面视角。
