Division of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Division of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Biochim Biophys Acta Mol Cell Res. 2020 Jul;1867(7):118641. doi: 10.1016/j.bbamcr.2019.118641. Epub 2019 Dec 30.
Cilia are ubiquitous in mammalian cells. The formation and assembly of cilia depend on the normal functioning of the ciliary transport system. In recent years, various proteins involved in the intracellular transport of the cilium have attracted attention, as many diseases are caused by disorders in cilia formation. Intraflagellar transport 20 (IFT20) is a subunit of IFT complex B, which contains approximately 20 protein particles. Studies have shown that defects in IFT20 are associated with numerous system -related diseases, such as those of the urinary system, cardiovascular system, skeletal system, nervous system, immune system, reproductive system, and respiratory system. This review summarizes current research on IFT20.We describe studies related to the role of IFT20 in cilia formation and discuss new targets for treating diseases associated with ciliary dysplasia.
纤毛在哺乳动物细胞中普遍存在。纤毛的形成和组装依赖于纤毛运输系统的正常功能。近年来，参与纤毛内运输的各种蛋白质引起了人们的关注，因为许多疾病是由纤毛形成障碍引起的。鞭毛内运输 20（IFT20）是 IFT 复合物 B 的一个亚基，包含大约 20 个蛋白颗粒。研究表明，IFT20 的缺陷与许多系统相关的疾病有关，如泌尿系统、心血管系统、骨骼系统、神经系统、免疫系统、生殖系统和呼吸系统疾病。本综述总结了目前关于 IFT20 的研究。我们描述了与 IFT20 在纤毛形成中的作用相关的研究，并讨论了治疗与纤毛发育不良相关疾病的新靶点。
