Yin Naiyi, Han Zeliang, Jia Wenbin, Fu Yaqi, Ma Jingnan, Liu Xiaotong, Cai Xiaolin, Li Yan, Chen Xiaochen, Cui Yanshan
College of Resources and Environment, University of Chinese Academy of Sciences, Beijing 101408, China; Research Center for Eco-Environment Sciences, Chinese Academy of Sciences, Beijing 100085, China.
College of Resources and Environment, University of Chinese Academy of Sciences, Beijing 101408, China; Fujian Provincial Engineering Research Center of Rural Waste Recycling Technology, College of Environment and Safety Engineering, Fuzhou University, Fuzhou 350108, China.
Ecotoxicol Environ Saf. 2022 Sep 15;243:113968. doi: 10.1016/j.ecoenv.2022.113968. Epub 2022 Aug 15.
Effects of vitamin C supplementation on the oral bioaccessibility of lead (Pb) present in contaminated soils were examined using a number of in vitro assays (PBET, SBRC, UBM and IVG). In the presence of vitamin C, an increase in Pb bioaccessibility was observed in the gastric phase by 1.3-fold (30.5%-85.5%) and in the intestinal phase by 3.1-fold (0.9%-58.9%). Lead mobilization was regulated by reductive dissolution of Fe(III) and sequestration of Pb on secondary Fe minerals. Sequential extraction by the Bureau Community of Reference (BCR) provided more evidence that reducible fraction and residual fraction were major contributor of gastric Pb bioaccessibility, as well as reduced fractions in intestinal Pb bioaccessibility. In addition, higher non-carcinogenic risks may occur based on target hazard quotient (THQ ≥ 1). For people exposed to Pb present in soil, the management of vitamin C supplements is of serious concern.
使用多种体外试验（PBET、SBRC、UBM和IVG）研究了补充维生素C对污染土壤中铅（Pb）的口腔生物可及性的影响。在维生素C存在的情况下，胃相中铅的生物可及性增加了1.3倍（30.5%-85.5%），肠相中增加了3.1倍（0.9%-58.9%）。铅的迁移受Fe(III)的还原溶解和Pb在次生铁矿物上的螯合作用调控。参考物质局（BCR）的连续提取提供了更多证据，表明可还原部分和残留部分是胃中铅生物可及性的主要贡献者，也是肠中铅生物可及性降低部分的主要贡献者。此外，基于目标危害商（THQ≥1）可能会出现更高的非致癌风险。对于接触土壤中铅的人群，维生素C补充剂的管理至关重要。
