College of Resources and Environment, University of Chinese Academy of Sciences, Beijing 101408, PR China; Research Center for Eco-Environment Sciences, Chinese Academy of Sciences, Beijing 100085, PR China.
College of Resources and Environment, University of Chinese Academy of Sciences, Beijing 101408, PR China; Research Center for Eco-Environment Sciences, Chinese Academy of Sciences, Beijing 100085, PR China.
Ecotoxicol Environ Saf. 2024 Sep 15;283:116808. doi: 10.1016/j.ecoenv.2024.116808. Epub 2024 Jul 30.
Exposure to arsenic (As) induces adverse effects on human health. Vitamins B1, B6, and C, as indispensable micronutrients for humans, have been proven to influence the metabolism and toxicity of ingested As. To determine the effect of vitamins on health risks associated with soil exposure, As bioaccessibility in 14 soil samples using four in vitro methods of IVG, PBET, SBRC, and UBM was measured with the addition of vitamins B1, B6, and C. With vitamins B1 and B6 addition, the gastric As bioaccessibility in 14 soil samples was reduced by 1.14-3.52 and 1.14-5.02 fold, respectively, and instead an increase in the intestinal bioaccessibility was presented in some cases. Vitamin C supplementation yielded higher As bioaccessibility in the gastric (1.13-13.02 fold) and small intestinal (1.21-33.35 fold) phases, respectively. As evidenced by the X-ray absorption near-edge spectroscopy (XANES) and Fourier transform infrared spectroscopy (FTIR) analysis, arsenic dissolution was promoted by Fe-As and hindered by the formation of Al-As fractions. Soil As dissolution in the simulated gastrointestinal tract was strongly influenced by soil minerals and ingested vitamins, due to the chelation of arsenic with vitamins and soil minerals such as Fe (hydr)oxides, and Fe(III) reductive dissolution to enhance As release by vitamin C as an iron reducer. These findings will expand the knowledge of health risks of exposure to As-contaminated soils and nutritional interventions aiming at the mitigation of As toxicity.
砷（As）暴露会对人类健康产生不良影响。维生素 B1、B6 和 C 是人类必需的微量营养素，已被证明会影响摄入的砷的代谢和毒性。为了确定维生素对与土壤暴露相关的健康风险的影响，使用 IVG、PBET、SBRC 和 UBM 四种体外方法测量了 14 个土壤样本中维生素 B1、B6 和 C 存在时的砷生物可给性。添加维生素 B1 和 B6 后，14 个土壤样本中的胃砷生物可给性分别降低了 1.14-3.52 倍和 1.14-5.02 倍，而在某些情况下肠内生物可给性增加。维生素 C 的补充使胃（1.13-13.02 倍）和小肠（1.21-33.35 倍）阶段的砷生物可给性更高。X 射线吸收近边光谱（XANES）和傅里叶变换红外光谱（FTIR）分析表明，砷的溶解受到 Fe-As 的促进，而 Al-As 分数的形成则阻碍了砷的溶解。模拟胃肠道中土壤砷的溶解受到土壤矿物质和摄入维生素的强烈影响，这是由于砷与维生素和土壤矿物质（如 Fe（氢）氧化物）形成螯合物，以及维生素 C 作为铁还原剂促进 Fe(III)还原溶解从而增强砷释放。这些发现将扩大对接触受污染土壤的砷和旨在减轻砷毒性的营养干预的健康风险的认识。
