State Key Laboratory for Mechanical Behavior of Materials, Shaanxi International Research Center for Soft Matter, School of Materials Science and Engineering, Xi'an Jiaotong University, Xi'an 710049, P. R. China.
School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, P. R. China.
ACS Appl Mater Interfaces. 2022 Aug 31;14(34):38594-38603. doi: 10.1021/acsami.2c11662. Epub 2022 Aug 18.
Metallacages with suitable cavities and specific functions are promising delivery vectors in biological systems. Herein, we report a morpholine-functionalized metallacage for lysosome-targeted cell imaging. The efficient host-guest interactions between the metallacage and dyes prevent them from aggregation, so their emission in aqueous solutions is well maintained. The fluorescence quantum yield of these host-guest complexes reaches 74.40%. Therefore, the metallacage is further employed as a vector to deliver dyes with different emission colors (blue, green, and red) into lysosomes for targeted imaging. This research affords a type of vector for the delivery of various cargos toward biological applications, which will enrich the usage of metallacages in biomedical engineering.
具有合适空腔和特定功能的金属笼是生物系统中很有前途的递药载体。在此，我们报道了一种吗啉功能化的金属笼，用于溶酶体靶向细胞成像。金属笼与染料之间有效的主客体相互作用阻止了它们的聚集，因此它们在水溶液中的发射得到了很好的保持。这些主客体配合物的荧光量子产率达到 74.40%。因此，该金属笼进一步被用作载体，将具有不同发射颜色（蓝色、绿色和红色）的染料递送至溶酶体进行靶向成像。这项研究为递送至生物应用的各种载体提供了一种类型，这将丰富金属笼在生物医学工程中的应用。
