Zhang Yu, Guan Shao-Qi, Wang Ya-Ping, Pan Mei
MOE Laboratory of Bioinorganic and Synthetic Chemistry, Lehn Institute of Functional Materials, IGCME, GBRCE for Functional Molecular Engineering, School of Chemistry, Sun Yat-sen University, Guangzhou 510006, China.
Molecules. 2025 May 31;30(11):2430. doi: 10.3390/molecules30112430.
In recent years, an increasing number of studies have shown that novel metal complexes with bio-imaging capabilities could enhance precision oncology, particularly through optimized photosensitizer (PS) design for subcellular organelle targeting photodynamic therapy (PDT). Based on this, we successfully developed a two-photon (TP) fluorescent Zn(II) complex, LIFM-ZY-3, characterized by the specifical targeting capability of lysosome. This complex was capable of monitoring dual changes in pH and viscosity. Additionally, our findings indicated that the complex could generate multiple reactive oxygen species (ROS), including singlet oxygen (O), hydroxyl radicals (•OH), and superoxide anion radicals (O) under white light irradiation in vivo and in vitro. These findings underscored the remarkable versatility of LIFM-ZY-3 as an advanced multifunctional PS for both microenvironment monitoring and tumor therapy.
近年来，越来越多的研究表明，具有生物成像能力的新型金属配合物可以提高肿瘤精准治疗水平，特别是通过优化用于亚细胞器靶向光动力疗法（PDT）的光敏剂（PS）设计。基于此，我们成功开发了一种双光子（TP）荧光锌（II）配合物LIFM-ZY-3，其特点是对溶酶体具有特异性靶向能力。该配合物能够监测pH值和粘度的双重变化。此外，我们的研究结果表明，该配合物在体内和体外白光照射下均可产生活性氧（ROS），包括单线态氧（O）、羟基自由基（•OH）和超氧阴离子自由基（O）。这些发现凸显了LIFM-ZY-3作为一种先进的多功能PS在微环境监测和肿瘤治疗方面的卓越通用性。
