Decreased skin superoxide dismutase activity by a single exposure of ultraviolet radiation is reduced by liposomal superoxide dismutase pretreatment.

The effect of a single exposure to UV radiation on skin superoxide dismutase (SOD) activity was examined in mice. A significant decrease in SOD activity was observed 24 and 48 h after UV irradiation, returning to the normal level by 72 h after irradiation. Decreased SOD activity after UV exposure was reduced by pretreatment with liposomal SOD (L-SOD). This protective effect of L-SOD may have potential clinical application for photodermatologic reactions.