Cardiovascular Division, Department of Internal Medicine, MacKay Memorial Hospital, MacKay Medical College, New Taipei City, Taiwan, ROC.
MacKay Junior College of Medicine, Nursing and Management, Taipei, Taiwan, ROC.
Sci Rep. 2022 Aug 18;12(1):14014. doi: 10.1038/s41598-022-18499-9.
Visceral adipose tissue (VAT) is associated with central obesity, insulin resistance and metabolic syndrome. However, the association of body-site specific adiposity and non-alcoholic fatty liver disease (NAFLD) has not been well characterized. We studies 704 consecutive subjects who underwent annual health survey in Taiwan. All subjects have been divided into three groups including normal (341), mild (227) and moderate and severe (136) NAFLD according to ultrasound finding. Pericardial (PCF) and thoracic peri-aortic adipose tissue (TAT) burden was assessed using a non-contrast 16-slice multi-detector computed tomography (MDCT) dataset with off-line measurement (Aquarius 3DWorkstation, TeraRecon, SanMateo, CA, USA). We explored the relationship between PCF/TAT, NAFLD and cardiometabolic risk profiles. Patients with moderate and mild NAFLD have greater volume of PCF (100.7 ± 26.3vs. 77.1 ± 21.3 vs. 61.7 ± 21.6 ml, P < 0.001) and TAT (11.2 ± 4.1 vs. 7.6 ± 2.6 vs. 5.5 ± 2.6 ml, P < 0.001) when compared to the normal groups. Both PCF and TAT remained independently associated with NAFLD after counting for age, sex, triglyceride, cholesterol and other cardiometabolic risk factors. In addition, both PCF and TAT provided incremental prediction value for NAFLD diagnosis. (AUROC: 0.85 and 0.87, 95%, confidence interval: 0.82-0.89 and 0.84-0.90). Both visceral adipose tissues strongly correlated with the severity of NAFLD. Compared to PCF, TAT is more tightly associated with NAFLD diagnosis in a large Asian population.
内脏脂肪组织（VAT）与中心性肥胖、胰岛素抵抗和代谢综合征有关。然而，身体特定部位的肥胖与非酒精性脂肪性肝病（NAFLD）之间的关联尚未得到很好的描述。我们对在台湾接受年度健康检查的 704 例连续患者进行了研究。根据超声检查结果，所有患者被分为三组：正常组（341 例）、轻度组（227 例）和中重度组（136 例）。使用 Aquarius 3DWorkstation（TeraRecon，SanMateo，CA，USA）对非对比 16 层多探测器 CT（MDCT）数据集进行心包脂肪（PCF）和胸主动脉周围脂肪组织（TAT）负荷评估。我们探讨了 PCF/TAT 与 NAFLD 和心血管代谢风险特征之间的关系。中、轻度 NAFLD 患者的 PCF 体积更大（100.7±26.3 vs. 77.1±21.3 vs. 61.7±21.6 ml，P<0.001）和 TAT（11.2±4.1 vs. 7.6±2.6 vs. 5.5±2.6 ml，P<0.001），与正常组相比。在考虑年龄、性别、甘油三酯、胆固醇和其他心血管代谢危险因素后，PCF 和 TAT 仍然与 NAFLD 独立相关。此外，PCF 和 TAT 对 NAFLD 的诊断均提供了增量预测值。（AUROC：0.85 和 0.87，95%置信区间：0.82-0.89 和 0.84-0.90）。两种内脏脂肪组织均与 NAFLD 的严重程度强烈相关。与 PCF 相比，TAT 与亚洲人群中 NAFLD 诊断的相关性更强。
