鼻唇溃疡斑块揭示原发性皮肤侵袭性亲表皮性CD8+ T细胞淋巴瘤。
Nasolabial Ulcerated Placard Revealing a Primary Cutaneous Aggressive Epidermotropic CD8+ T-cell Lymphoma.
作者信息
Ntihebuwayo J B, Hali F, Kerouach A, Rachadi H, Chiheb S, Marnissi F
机构信息
Dermatology and Venereology Department, Ibn Rochd University Hospital-Casablanca, Casablanca, Morocco.
Laboratory of Pathological Anatomy, Ibn Rochd University Hospital-Casablanca, Casablanca, Morocco.
出版信息
Case Rep Dermatol Med. 2022 Aug 9;2022:5672783. doi: 10.1155/2022/5672783. eCollection 2022.
Primary cutaneous aggressive epidermotropic CD8+ T-cell lymphoma is a rare entity representing less than 1% of cutaneous lymphomas. It has an aggressive clinical manifestation with a poor prognosis. It is characterized by cytotoxic and epidermotropic CD8+ proliferation. It also expresses the TIA-1 marker. We report a new case for its display and aggressive character, diagnostic difficulty, and good therapeutic response to chemotherapy. This is a 62-year-old female patient admitted to the hospital for a nasolabial ulcerated placard evolving for two years. Clinical examination revealed submandibular lymph nodes. The specimen analysis associated with anatomoclinical manifestation was concluded for a primary cutaneous aggressive epidermotropic CD8+ T-cell lymphoma. Tumor extent assessment did not show any secondary localization. The blood tests and serology were unremarkable. The patient had benefited from a CHOEP-type multidrug therapy protocol with complete healing of the lesion after three courses of chemotherapy.
原发性皮肤侵袭性亲表皮CD8 + T细胞淋巴瘤是一种罕见的疾病，占皮肤淋巴瘤的比例不到1%。它具有侵袭性的临床表现，预后较差。其特征为细胞毒性和亲表皮的CD8 +增殖。它还表达TIA-1标志物。我们报告一例新病例，展示其侵袭性特征、诊断困难以及对化疗良好的治疗反应。这是一名62岁女性患者，因鼻唇溃疡斑块入院，病程已两年。临床检查发现下颌下淋巴结。结合解剖学临床表现的标本分析诊断为原发性皮肤侵袭性亲表皮CD8 + T细胞淋巴瘤。肿瘤范围评估未显示任何继发性定位。血液检查和血清学检查无异常。该患者接受了CHOEP方案的多药治疗，化疗三个疗程后病变完全愈合。
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