Wu En-Ling, Al-Heeti Omar, Hoff Brian M, Williams Janna L, Krueger Karen M, Santoiemma Phillip P, Rhodes Nathaniel J
Division of Infectious Diseases, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Department of Pharmacy, Loyola University Medical Center, Maywood, Illinois, USA.
Open Forum Infect Dis. 2022 Jul 30;9(8):ofac392. doi: 10.1093/ofid/ofac392. eCollection 2022 Aug.
A patient presenting with recurrent ventriculoperitoneal shunt infection was found to have growing from cerebrospinal fluid (CSF), which remained persistently positive. Therapeutic monitoring of clarithromycin, imipenem, and linezolid in CSF and plasma revealed lower than expected concentrations, prompting alternative therapy and culture clearance on hospital day 42.
一名出现复发性脑室腹腔分流感染的患者，其脑脊液（CSF）培养发现有细菌生长，且该培养结果持续呈阳性。对脑脊液和血浆中的克拉霉素、亚胺培南和利奈唑胺进行治疗监测发现，其浓度低于预期，因此在住院第42天更换了治疗方案并清除了培养物中的细菌。
