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健康儿童受试者脑脊液流动动力学的电影相位对比磁共振成像评估

Cine phase-contrast magnetic resonance imaging evaluation of cerebrospinal fluid flow dynamics in healthy pediatric subjects.

作者信息

Plata Karen Sousa, Cruz Gerardo, Lezcano Hector

机构信息

Hospital Santo Tomás, Panama City, Panama.

Dr. Arnulfo Arias Madrid Hospital, Panama City, Panama.

出版信息

Radiol Bras. 2022 Jul-Aug;55(4):225-230. doi: 10.1590/0100-3984.2021.0120.

DOI:10.1590/0100-3984.2021.0120
PMID:35983345
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9380615/
Abstract

OBJECTIVE

To evaluate cerebrospinal fluid dynamics, using cine phase-contrast magnetic resonance imaging (cine-PC MRI), in healthy pediatric subjects, determining the normal flow values in this population, as well as identifying differences related to age, sex, and body surface area.

MATERIALS AND METHODS

This was a descriptive cross-sectional study involving 32 healthy children and adolescents, in whom the flow of cerebrospinal fluid through the cerebral aqueduct was evaluated quantitatively with cine-PC MRI. We used specialized software to analyze the images obtained with cine-PC MRI, drawing a region of interest on the aqueduct. A flow-time curve was obtained, as were automated measurements of the various parameters.

RESULTS

The following normal (mean) values were obtained: net flow, 1.10 ± 0.99 mL/m; stroke volume, 12.2 ± 10.1 µL/cycle; mean velocity, 0.72 ± 1.00 cm/s; peak systolic velocity, 5.28 ± 2.30 cm/s; peak diastolic velocity, 4.51 ± 1.77 cm/s. These values were not affected by age or sex. In addition, body surface area was not found to correlate significantly with mean velocity or stroke volume.

CONCLUSION

In children and adolescents, the basic cerebrospinal fluid flow parameters, as determined by cine-PC MRI, appear to be independent of age and sex.

摘要

目的

使用电影相位对比磁共振成像（cine-PC MRI）评估健康儿童受试者的脑脊液动力学，确定该人群的正常流量值，并识别与年龄、性别和体表面积相关的差异。

材料与方法

这是一项描述性横断面研究，涉及32名健康儿童和青少年，通过cine-PC MRI对脑脊液通过中脑导水管的流量进行定量评估。我们使用专门的软件分析cine-PC MRI获得的图像，在导水管上绘制感兴趣区域。获得了流量-时间曲线以及各种参数的自动测量值。

结果

获得以下正常（平均）值：净流量，1.10±0.99 mL/m；每搏量，12.2±10.1 μL/周期；平均速度，0.72±1.00 cm/s；收缩期峰值速度，5.28±2.30 cm/s；舒张期峰值速度，4.51±1.77 cm/s。这些值不受年龄或性别的影响。此外，未发现体表面积与平均速度或每搏量有显著相关性。

结论

在儿童和青少年中，由cine-PC MRI确定的基本脑脊液流动参数似乎与年龄和性别无关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db0c/9380615/cef44d3ae16a/rb-55-04-0225-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db0c/9380615/44a803f01099/rb-55-04-0225-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db0c/9380615/a087a08bb541/rb-55-04-0225-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db0c/9380615/7381f94636df/rb-55-04-0225-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db0c/9380615/cef44d3ae16a/rb-55-04-0225-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db0c/9380615/44a803f01099/rb-55-04-0225-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db0c/9380615/a087a08bb541/rb-55-04-0225-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db0c/9380615/7381f94636df/rb-55-04-0225-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db0c/9380615/cef44d3ae16a/rb-55-04-0225-g04.jpg

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