血清学辅助筛查 COVID-19。
Auxiliary Screening COVID-19 by Serology.
机构信息
Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, China.
Department of Mathematics and Statistics, Mzuzu University, Mzuzu, Malawi.
出版信息
Front Public Health. 2022 Aug 2;10:819841. doi: 10.3389/fpubh.2022.819841. eCollection 2022.
BACKGROUND
The 2019 novel coronavirus (COVID-19) pandemic remains rampant in many countries/regions. Improving the positive detection rate of COVID-19 infection is an important measure for control and prevention of this pandemic. This meta-analysis aims to systematically summarize the current characteristics of the auxiliary screening methods by serology for COVID-19 infection in real world.
METHODS
Web of Science, Cochrane Library, Embase, PubMed, CNKI, and Wangfang databases were searched for relevant articles published prior to May 1, 2022. Data on specificity, sensitivity, positive/negative likelihood ratio, area under curve (AUC), and diagnostic odds ratio (dOR) were calculated purposefully.
RESULTS
Sixty-two studies were included with 35,775 participants in the meta-analysis. Among these studies, the pooled estimates for area under the summary receiver operator characteristic of IgG and IgM to predicting COVID-19 diagnosis were 0.974 and 0.928, respectively. The IgG dOR was 209.78 (95% CI: 106.12 to 414.67). The IgM dOR was 78.17 (95% CI: 36.76 to 166.25).
CONCLUSION
Our findings support serum-specific antibody detection may be the main auxiliary screening methods for COVID-19 infection in real world.
背景
2019 年新型冠状病毒（COVID-19）大流行在许多国家/地区仍然猖獗。提高 COVID-19 感染的阳性检出率是控制和预防这一大流行的重要措施。本荟萃分析旨在系统总结目前血清学辅助筛查 COVID-19 感染的方法特征。
方法
检索了 Web of Science、Cochrane 图书馆、Embase、PubMed、CNKI 和万方数据库，以获取截至 2022 年 5 月 1 日之前发表的相关文章。有针对性地计算了特异性、敏感性、阳性/阴性似然比、曲线下面积（AUC）和诊断优势比（dOR）。
结果
荟萃分析共纳入 62 项研究，涉及 35775 名参与者。在这些研究中，用于预测 COVID-19 诊断的 IgG 和 IgM 的汇总接收者操作特性曲线下面积的合并估计值分别为 0.974 和 0.928。IgG 的 dOR 为 209.78（95%CI：106.12 至 414.67）。IgM 的 dOR 为 78.17（95%CI：36.76 至 166.25）。
结论
我们的研究结果支持血清特异性抗体检测可能是现实世界中 COVID-19 感染的主要辅助筛查方法。
Zotero 插件